BCL-X Dependence is a Subtype Agnostic Actionable Feature of Difficult-to-Treat Kidney Cancers. Basuroy T, Grubb T, Sadagopan A, et al. BCL-X Dependence is a Subtype Agnostic Actionable Feature of Difficult-to-Treat Kidney Cancers. bioRxiv : the preprint server for biology. 2025. doi:10.64898/2025.12.10.693422 PMCID PMC12710959 Read more
Proteomic profiling of Alzheimer's disease and Vascular dementia reveals unique underlying signatures. Amin N, Kaushik P, Belbasis L, et al. Proteomic profiling of Alzheimer’s disease and Vascular dementia reveals unique underlying signatures. medRxiv : the preprint server for health sciences. 2025. doi:10.64898/2025.12.08.25341836 PMCID PMC12709455 Read more
PCMT1 generates the C-terminal cyclic imide degron on CRBN substrates. Zhao Z, Xu W, Feng EY, et al. PCMT1 generates the C-terminal cyclic imide degron on CRBN substrates. Nature chemical biology. 2025. doi:10.1038/s41589-025-02106-9 Read more
Leveraging genomic and transcriptomic data of diverse ancestry to uncover mechanisms of psychiatric risk in the adult and developing brain. Jajoo A, Balakundi V, Chatzinakos C, et al. Leveraging genomic and transcriptomic data of diverse ancestry to uncover mechanisms of psychiatric risk in the adult and developing brain. Nature communications. 2025. doi:10.1038/s41467-025-67941-9 Read more
Cell-DINO: Self-supervised image-based embeddings for cell fluorescent microscopy. Moutakanni T, Couprie C, Yi S, et al. Cell-DINO: Self-supervised image-based embeddings for cell fluorescent microscopy. PLoS computational biology. 2025;21(12):e1013828. doi:10.1371/journal.pcbi.1013828 Read more
Structurally related phage helicases trigger type III-A3 retron-mediated anti-phage defense across diverse tailed phage families. GarcÃa-RodrÃguez FM, MartÃnez-Abarca F, González-Delgado A, et al. Structurally related phage helicases trigger type III-A3 retron-mediated anti-phage defense across diverse tailed phage families. Nucleic acids research. 2025;53(22). doi:10.1093/nar/gkaf1396 Read more
MAPK Pathway Mutations Emerge in Mutant-IDH1 Inhibitor-Resistant Cholangiocarcinoma and Attenuate the Interferon Response. Wan J, Saatcioglu HD, Ellis H, et al. MAPK Pathway Mutations Emerge in Mutant-IDH1 Inhibitor-Resistant Cholangiocarcinoma and Attenuate the Interferon Response. Clinical cancer research : an official journal of the American Association for Cancer Research. 2025. doi:10.1158/1078-0432.CCR-25-3284 Read more
LARIS enables accurate and efficient ligand and receptor interaction analysis in spatial transcriptomics. Dai M, Török T, Sun D, et al. LARIS enables accurate and efficient ligand and receptor interaction analysis in spatial transcriptomics. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.11.26.690796 PMCID PMC12697369 Read more
Anti-CRISPR-mediated continuous directed evolution of CRISPR-Cas9 in human cells. Sabol AL, Mengiste AA, Sreekanth V, et al. Anti-CRISPR-mediated continuous directed evolution of CRISPR-Cas9 in human cells. bioRxiv : the preprint server for biology. 2025. doi:10.64898/2025.12.11.693673 PMCID PMC12710652 Read more
Automatic detection of n-degree family members. Pedersen EM, Steinbach J, Pedersen CB, et al. Automatic detection of n-degree family members. Frontiers in genetics. 2025;16:1708315. doi:10.3389/fgene.2025.1708315 PMCID PMC12741096 Read more