ӳ��ý

Publications

A pan-tissue survey of mosaic chromosomal alterations in 948 individuals.

Gao T, Kastriti ME, Ljungström V, et al. A pan-tissue survey of mosaic chromosomal alterations in 948 individuals. Nature genetics. 2023;55(11):1901-1911. doi:10.1038/s41588-023-01537-1

Genomic insights into the mechanisms of FGFR1 dependency in squamous cell lung cancer.

Mäkinen N, Meyerson M. Genomic insights into the mechanisms of FGFR1 dependency in squamous cell lung cancer. The Journal of clinical investigation. 2023;133(21). doi:10.1172/JCI174171

Somatic TET2 Mutations are Associated with Giant Cell Arteritis.

Robinette ML, Weeks LD, Kramer RJ, et al. Somatic TET2 Mutations are Associated with Giant Cell Arteritis. Arthritis & rheumatology (Hoboken, N.J.). 2023. doi:10.1002/art.42738

Allosteric PI3K-alpha inhibition overcomes on-target resistance to orthosteric inhibitors mediated by secondary PIK3CA mutations.

Varkaris A, de la Cruz FF, Martin EE, et al. Allosteric PI3K-alpha inhibition overcomes on-target resistance to orthosteric inhibitors mediated by secondary PIK3CA mutations. Cancer discovery. 2023. doi:10.1158/2159-8290.CD-23-0704

Multiple-instance learning of somatic mutations for the classification of tumour type and the prediction of microsatellite status.

Anaya J, Sidhom JW, Mahmood F, Baras AS. Multiple-instance learning of somatic mutations for the classification of tumour type and the prediction of microsatellite status. Nature biomedical engineering. 2023. doi:10.1038/s41551-023-01120-3

A Purkinje cell to parabrachial nucleus pathway enables broad cerebellar influence over the forebrain.

Chen CH, Newman LN, Stark AP, et al. A Purkinje cell to parabrachial nucleus pathway enables broad cerebellar influence over the forebrain. Nature neuroscience. 2023;26(11):1929-1941. doi:10.1038/s41593-023-01462-w

Mathematical Modeling Identifies Optimum Palbociclib-fulvestrant Dose Administration Schedules for the Treatment of Patients with Estrogen Receptor-positive Breast Cancer.

Cheng YC, Stein S, Nardone A, et al. Mathematical Modeling Identifies Optimum Palbociclib-fulvestrant Dose Administration Schedules for the Treatment of Patients with Estrogen Receptor-positive Breast Cancer. Cancer research communications. 2023;3(11):2331-2344. doi:10.1158/2767-9764.CRC-23-0257

Functional screening of amplification outlier oncogenes in organoid models of early tumorigenesis.

Salahudeen AA, Seoane JA, Yuki K, et al. Functional screening of amplification outlier oncogenes in organoid models of early tumorigenesis. Cell reports. 2023;42(11):113355. doi:10.1016/j.celrep.2023.113355

Specific heterozygous variants in MGP lead to endoplasmic reticulum stress and cause spondyloepiphyseal dysplasia.

Gourgas O, Lemire G, Eaton AL, et al. Specific heterozygous variants in MGP lead to endoplasmic reticulum stress and cause spondyloepiphyseal dysplasia. Nature communications. 2023;14(1):7054. doi:10.1038/s41467-023-41651-6

Identification of circulating proteins associated with general cognitive function among middle-aged and older adults.

Tin A, Fohner AE, Yang Q, et al. Identification of circulating proteins associated with general cognitive function among middle-aged and older adults. Communications biology. 2023;6(1):1117. doi:10.1038/s42003-023-05454-1