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Publications

Polygenic Background Modifies Risk of Coronary Artery Disease Among Individuals With Heterozygous Familial Hypercholesterolemia.

Reeskamp LF, Shim I, Dron JS, et al. Polygenic Background Modifies Risk of Coronary Artery Disease Among Individuals With Heterozygous Familial Hypercholesterolemia. JACC. Advances. 2023;2(9):100662. doi:10.1016/j.jacadv.2023.100662

"LOGGIC" of RNA-sequencing in enhancing diagnoses of pediatric low-grade gliomas.

Apfelbaum A, Bandopadhayay P. "LOGGIC" of RNA-sequencing in enhancing diagnoses of pediatric low-grade gliomas. Neuro-oncology. 2023;25(11):2098-2099. doi:10.1093/neuonc/noad142

DHODH: a promising target in the treatment of T-cell acute lymphoblastic leukemia.

Sexauer AN, Alexe G, Gustafsson K, et al. DHODH: a promising target in the treatment of T-cell acute lymphoblastic leukemia. Blood advances. 2023;7(21):6685-6701. doi:10.1182/bloodadvances.2023010337

KRAS Wild-Type Pancreatic Cancer: Decoding Genomics, Unlocking Therapeutic Potential.

Kato H, Ellis H, Bardeesy N. KRAS Wild-Type Pancreatic Cancer: Decoding Genomics, Unlocking Therapeutic Potential. Clinical cancer research : an official journal of the American Association for Cancer Research. 2023;29(22):4527-4529. doi:10.1158/1078-0432.CCR-23-2221

GLUT3 promotes macrophage signaling and function via RAS-mediated endocytosis in atopic dermatitis and wound healing.

Yu DM, Zhao J, Lee EE, et al. GLUT3 promotes macrophage signaling and function via RAS-mediated endocytosis in atopic dermatitis and wound healing. The Journal of clinical investigation. 2023;133(21). doi:10.1172/JCI170706

Integration of Genomic Sequencing Drives Therapeutic Targeting of PDGFRA in T-Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma.

Paolino J, Dimitrov B, Winger BA, et al. Integration of Genomic Sequencing Drives Therapeutic Targeting of PDGFRA in T-Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2023;29(22):4613-4626. doi:10.1158/1078-0432.CCR-22-2562

A paracrine circuit of IL-1β/IL-1R1 between myeloid and tumor cells drives genotype-dependent glioblastoma progression.

Chen Z, Giotti B, Kaluzova M, et al. A paracrine circuit of IL-1β/IL-1R1 between myeloid and tumor cells drives genotype-dependent glioblastoma progression. The Journal of clinical investigation. 2023;133(22). doi:10.1172/JCI163802

Association Between Bowel Movement Pattern and Cognitive Function: Prospective Cohort Study and a Metagenomic Analysis of the Gut Microbiome.

Ma C, Li Y, Mei Z, et al. Association Between Bowel Movement Pattern and Cognitive Function: Prospective Cohort Study and a Metagenomic Analysis of the Gut Microbiome. Neurology. 2023;101(20):e2014-e2025. doi:10.1212/WNL.0000000000207849

Functional genomics reveals an off-target dependency of drug synergy in gastric cancer therapy.

Leylek O, Honeywell ME, Lee MJ, Hemann MT, Ozcan G. Functional genomics reveals an off-target dependency of drug synergy in gastric cancer therapy. bioRxiv : the preprint server for biology. 2023. doi:10.1101/2023.10.07.561351

Risk factors for severe respiratory syncytial virus infection during the first year of life: development and validation of a clinical prediction model.

Vartiainen P, Jukarainen S, Rhedin SA, et al. Risk factors for severe respiratory syncytial virus infection during the first year of life: development and validation of a clinical prediction model. The Lancet. Digital health. 2023;5(11):e821-e830. doi:10.1016/S2589-7500(23)00175-9