Publications

Proteogenomic integration reveals CXCL10 as a potentially downstream causal mediator for IL-6 signaling on atherosclerosis.

Prapiadou S, Živković L, Thorand B, et al. Proteogenomic integration reveals CXCL10 as a potentially downstream causal mediator for IL-6 signaling on atherosclerosis. medRxiv : the preprint server for health sciences. 2023. doi:10.1101/2023.03.24.23287543

Integrative polygenic risk score improves the prediction accuracy of complex traits and diseases.

Truong B, Hull LE, Ruan Y, et al. Integrative polygenic risk score improves the prediction accuracy of complex traits and diseases. medRxiv : the preprint server for health sciences. 2023. doi:10.1101/2023.02.21.23286110

Distinct and shared genetic architectures of Gestational diabetes mellitus and Type 2 Diabetes Mellitus.

Elliott A, Walters RK, Pirinen M, et al. Distinct and shared genetic architectures of Gestational diabetes mellitus and Type 2 Diabetes Mellitus. medRxiv : the preprint server for health sciences. 2023. doi:10.1101/2023.02.16.23286014

A gene pathogenicity tool 'GenePy' identifies missed biallelic diagnoses in the 100,000 Genomes Project.

Seaby EG, Leggatt G, Cheng G, et al. A gene pathogenicity tool ’GenePy’ identifies missed biallelic diagnoses in the 100,000 Genomes Project. medRxiv : the preprint server for health sciences. 2023. doi:10.1101/2023.03.21.23287545

Untargeted metabolomics profiling in pediatric patients and adult populations indicates a connection between lipid imbalance and epilepsy.

Oja KT, Ilisson M, Reinson K, et al. Untargeted metabolomics profiling in pediatric patients and adult populations indicates a connection between lipid imbalance and epilepsy. medRxiv : the preprint server for health sciences. 2023. doi:10.1101/2023.03.29.23287640

Structurally divergent and recurrently mutated regions of primate genomes.

Mao Y, Harvey WT, Porubsky D, et al. Structurally divergent and recurrently mutated regions of primate genomes. bioRxiv : the preprint server for biology. 2023. doi:10.1101/2023.03.07.531415

Replicative stress in gastroesophageal adenocarcinoma is associated with chromosomal instability and sensitivity to DNA damage response inhibitors.

Sahgal P, Patil DT, Sztupinszki ZM, et al. Replicative stress in gastroesophageal adenocarcinoma is associated with chromosomal instability and sensitivity to DNA damage response inhibitors. bioRxiv : the preprint server for biology. 2023. doi:10.1101/2023.03.27.534412

Charting the cellular biogeography in colitis reveals fibroblast trajectories and coordinated spatial remodeling.

Cadinu P, Sivanathan KN, Misra A, et al. Charting the cellular biogeography in colitis reveals fibroblast trajectories and coordinated spatial remodeling. bioRxiv : the preprint server for biology. 2023. doi:10.1101/2023.05.08.539701

Rapid-kinetics degron benchmarking reveals off-target activities and mixed agonism-antagonism of MYB inhibitors.

Harada T, Perez MW, Kalfon J, et al. Rapid-kinetics degron benchmarking reveals off-target activities and mixed agonism-antagonism of MYB inhibitors. bioRxiv : the preprint server for biology. 2023. doi:10.1101/2023.04.07.536032

Identifying metabolic features of colorectal cancer liability using Mendelian randomization.

Bull CJ, Hazelwood E, Bell JA, et al. Identifying metabolic features of colorectal cancer liability using Mendelian randomization. medRxiv : the preprint server for health sciences. 2023. doi:10.1101/2023.03.10.23287084

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Publications

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