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Publications

A practical approach to curate clonal hematopoiesis of indeterminate potential in human genetic data sets.

Vlasschaert C, Mack T, Heimlich B, et al. A practical approach to curate clonal hematopoiesis of indeterminate potential in human genetic data sets. Blood. 2023;141(18):2214-2223. doi:10.1182/blood.2022018825

SIRT6 is a key regulator of mitochondrial function in the brain.

Smirnov D, Eremenko E, Stein D, et al. SIRT6 is a key regulator of mitochondrial function in the brain. Cell death & disease. 2023;14(1):35. doi:10.1038/s41419-022-05542-w

Questioning the fetal microbiome illustrates pitfalls of low-biomass microbial studies.

Kennedy KM, de Goffau MC, Perez-Muñoz ME, et al. Questioning the fetal microbiome illustrates pitfalls of low-biomass microbial studies. Nature. 2023;613(7945):639-649. doi:10.1038/s41586-022-05546-8

Genetic analyses implicate complex links between adult testosterone levels and health and disease.

Leinonen JT, Mars N, Lehtonen LE, et al. Genetic analyses implicate complex links between adult testosterone levels and health and disease. Communications medicine. 2023;3(1):4. doi:10.1038/s43856-022-00226-0

Cross-ancestry genome-wide analysis of atrial fibrillation unveils disease biology and enables cardioembolic risk prediction.

Miyazawa K, Ito K, Ito M, et al. Cross-ancestry genome-wide analysis of atrial fibrillation unveils disease biology and enables cardioembolic risk prediction. Nature genetics. 2023;55(2):187-197. doi:10.1038/s41588-022-01284-9

Liver-specific FGFR4 knockdown in mice on an HFD increases bile acid synthesis and improves hepatic steatosis.

Moreau F, Brunao BB, Liu XY, et al. Liver-specific FGFR4 knockdown in mice on an HFD increases bile acid synthesis and improves hepatic steatosis. Journal of lipid research. 2023;64(2):100324. doi:10.1016/j.jlr.2022.100324

High-efficiency purification of divergent AAV serotypes using AAVX affinity chromatography.

Florea M, Nicolaou F, Pacouret S, et al. High-efficiency purification of divergent AAV serotypes using AAVX affinity chromatography. Molecular therapy. Methods & clinical development. 2023;28:146-159. doi:10.1016/j.omtm.2022.12.009

Distinct COPD subtypes in former smokers revealed by gene network perturbation analysis.

Buschur KL, Riley C, Saferali A, et al. Distinct COPD subtypes in former smokers revealed by gene network perturbation analysis. Respiratory research. 2023;24(1):30. doi:10.1186/s12931-023-02316-6

The 2022 RSV surge was driven by multiple viral lineages.

Adams G, Moreno GK, Petros BA, et al. The 2022 RSV surge was driven by multiple viral lineages. medRxiv : the preprint server for health sciences. 2023. doi:10.1101/2023.01.04.23284195

Low protease activity in B cell follicles promotes retention of intact antigens after immunization.

Aung A, Cui A, Maiorino L, et al. Low protease activity in B cell follicles promotes retention of intact antigens after immunization. Science (New York, N.Y.). 2023;379(6630):eabn8934. doi:10.1126/science.abn8934