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Publications

Olfactory neuronal cells as a promising tool to realize the "druggable genome" approach for drug discovery in neuropsychiatric disorders.

Mihaljevic M, Lam M, Ayala-Grosso C, et al. Olfactory neuronal cells as a promising tool to realize the "druggable genome" approach for drug discovery in neuropsychiatric disorders. Frontiers in neuroscience. 2022;16:1081124. doi:10.3389/fnins.2022.1081124

Multi-ancestry meta-analysis of asthma identifies novel associations and highlights the value of increased power and diversity.

Tsuo K, Zhou W, Wang Y, et al. Multi-ancestry meta-analysis of asthma identifies novel associations and highlights the value of increased power and diversity. Cell genomics. 2022;2(12):100212. doi:10.1016/j.xgen.2022.100212

Genomic discoveries unveil mechanistic insights in diabetes.

Florez JC. Genomic discoveries unveil mechanistic insights in diabetes. Cell genomics. 2022;2(12):100230. doi:10.1016/j.xgen.2022.100230

Greater genetic diversity is needed in human pluripotent stem cell models.

Ghosh S, Nehme R, Barrett LE. Greater genetic diversity is needed in human pluripotent stem cell models. Nat Commun. 2022;13(1):7301. doi:10.1038/s41467-022-34940-z

Single cell characterization of myeloma and its precursor conditions reveals transcriptional signatures of early tumorigenesis.

Boiarsky R, Haradhvala NJ, Alberge JB, et al. Single cell characterization of myeloma and its precursor conditions reveals transcriptional signatures of early tumorigenesis. Nat Commun. 2022;13(1):7040. doi:10.1038/s41467-022-33944-z

A general approach to identify cell-permeable and synthetic anti-CRISPR small molecules.

Lim D, Zhou Q, Cox KJ, et al. A general approach to identify cell-permeable and synthetic anti-CRISPR small molecules. Nat Cell Biol. 2022. doi:10.1038/s41556-022-01005-8

Systemic administration of novel engineered AAV capsids facilitates enhanced transgene expression in the macaque CNS.

Stanton AC, Lagerborg KA, Tellez L, et al. Systemic administration of novel engineered AAV capsids facilitates enhanced transgene expression in the macaque CNS. Med (N Y). 2022. doi:10.1016/j.medj.2022.11.002

Immune biomarkers of response to immunotherapy in patients with high-risk smoldering myeloma.

Sklavenitis-Pistofidis R, Aranha MP, Redd RA, et al. Immune biomarkers of response to immunotherapy in patients with high-risk smoldering myeloma. Cancer Cell. 2022;40(11):1358-1373.e8. doi:10.1016/j.ccell.2022.10.017

Evolution of an adenine base editor into a small, efficient cytosine base editor with low off-target activity.

Neugebauer ME, Hsu A, Arbab M, et al. Evolution of an adenine base editor into a small, efficient cytosine base editor with low off-target activity. Nat Biotechnol. 2022. doi:10.1038/s41587-022-01533-6

High-dimensional gene expression and morphology profiles of cells across 28,000 genetic and chemical perturbations.

Haghighi M, Caicedo JC, Cimini BA, Carpenter AE, Singh S. High-dimensional gene expression and morphology profiles of cells across 28,000 genetic and chemical perturbations. Nat Methods. 2022. doi:10.1038/s41592-022-01667-0