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Publications

Statistical and functional convergence of common and rare genetic influences on autism at chromosome 16p.

Weiner DJ, Ling E, Erdin S, et al. Statistical and functional convergence of common and rare genetic influences on autism at chromosome 16p. Nat Genet. 2022. doi:10.1038/s41588-022-01203-y

Disease stages and therapeutic hypotheses in two decades of neurodegenerative disease clinical trials.

Mortberg MA, Vallabh SM, Minikel EV. Disease stages and therapeutic hypotheses in two decades of neurodegenerative disease clinical trials. Sci Rep. 2022;12(1):17708. doi:10.1038/s41598-022-21820-1

Transcriptional and functional consequences of alterations to MEF2C and its topological organization in neuronal models.

Mohajeri K, Yadav R, D’haene E, et al. Transcriptional and functional consequences of alterations to MEF2C and its topological organization in neuronal models. Am J Hum Genet. 2022. doi:10.1016/j.ajhg.2022.09.015

A saturated map of common genetic variants associated with human height.

Yengo L, Vedantam S, Marouli E, et al. A saturated map of common genetic variants associated with human height. Nature. 2022. doi:10.1038/s41586-022-05275-y

Structure of the OMEGA nickase IsrB in complex with ωRNA and target DNA.

Hirano S, Kappel K, Altae-Tran H, et al. Structure of the OMEGA nickase IsrB in complex with ωRNA and target DNA. Nature. 2022. doi:10.1038/s41586-022-05324-6

The diverse genetic origins of a Classical period Greek army.

Reitsema LJ, Mittnik A, Kyle B, et al. The diverse genetic origins of a Classical period Greek army. Proc Natl Acad Sci U S A. 2022;119(41):e2205272119. doi:10.1073/pnas.2205272119

Spatial maps of T cell receptors and transcriptomes reveal distinct immune niches and interactions in the adaptive immune response.

Liu S, Iorgulescu B, Li S, et al. Spatial maps of T cell receptors and transcriptomes reveal distinct immune niches and interactions in the adaptive immune response. Immunity. 2022;55(10):1940-1952.e5. doi:10.1016/j.immuni.2022.09.002

Single-cell dissection of the obesity-exercise axis in adipose-muscle tissues implies a critical role for mesenchymal stem cells.

Yang J, Vamvini M, Nigro P, et al. Single-cell dissection of the obesity-exercise axis in adipose-muscle tissues implies a critical role for mesenchymal stem cells. Cell Metab. 2022;34(10):1578-1593.e6. doi:10.1016/j.cmet.2022.09.004

Multiscale profiling of protease activity in cancer.

Amini AP, Kirkpatrick JD, Wang CS, et al. Multiscale profiling of protease activity in cancer. Nat Commun. 2022;13(1):5745. doi:10.1038/s41467-022-32988-5

Integration of GWAS and brain transcriptomic analyses in a multiethnic sample of 35,245 older adults identifies DCDC2 gene as predictor of episodic memory maintenance.

Gao Y, Felsky D, Reyes-Dumeyer D, et al. Integration of GWAS and brain transcriptomic analyses in a multiethnic sample of 35,245 older adults identifies DCDC2 gene as predictor of episodic memory maintenance. Alzheimer’s & dementia : the journal of the Alzheimer’s Association. 2022;18(10):1797-1811. doi:10.1002/alz.12524

PMCID

PMC9170841