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Publications

A wealth of discovery built on the Human Genome Project - by the numbers.

Gates AJ, Gysi DM, Kellis M, Barabási AL. A wealth of discovery built on the Human Genome Project - by the numbers. Nature. 2021;590(7845):212-215. doi:10.1038/d41586-021-00314-6

Regulatory genomic circuitry of human disease loci by integrative epigenomics.

Boix CA, James BT, Park YP, Meuleman W, Kellis M. Regulatory genomic circuitry of human disease loci by integrative epigenomics. Nature. 2021;590(7845):300-307. doi:10.1038/s41586-020-03145-z

Noncanonical open reading frames encode functional proteins essential for cancer cell survival.

Prensner JR, Enache OM, Luria V, et al. Noncanonical open reading frames encode functional proteins essential for cancer cell survival. Nat Biotechnol. 2021. doi:10.1038/s41587-020-00806-2

Antigen identification for HLA class I- and HLA class II-restricted T cell receptors using cytokine-capturing antigen-presenting cells.

Lee MN, Meyerson M. Antigen identification for HLA class I- and HLA class II-restricted T cell receptors using cytokine-capturing antigen-presenting cells. Sci Immunol. 2021;6(55). doi:10.1126/sciimmunol.abf4001

Nailing Down a Notoriously Elusive Cancer Target: Direct Inhibition of MYC by a Covalent Small Molecule.

Henley MJ, Doyle SK, Koehler AN. Nailing Down a Notoriously Elusive Cancer Target: Direct Inhibition of MYC by a Covalent Small Molecule. Cell Chem Biol. 2021;28(1):1-3. doi:10.1016/j.chembiol.2020.12.014

GSK3α, not GSK3β, drives hippocampal NMDAR-dependent LTD via tau-mediated spine anchoring.

Draffin JE, Sánchez-Castillo C, Fernández-Rodrigo A, et al. GSK3α, not GSK3β, drives hippocampal NMDAR-dependent LTD via tau-mediated spine anchoring. EMBO J. 2021;40(2):e105513. doi:10.15252/embj.2020105513

Targeting pan-essential genes in cancer: challenges and opportunities.

Chang L, Ruiz P, Ito T, Sellers WR. Targeting pan-essential genes in cancer: challenges and opportunities. Cancer Cell. 2021. doi:10.1016/j.ccell.2020.12.008

Human Molecular Genetics and Genomics - Important Advances and Exciting Possibilities.

Collins FS, Doudna JA, Lander ES, Rotimi CN. Human Molecular Genetics and Genomics - Important Advances and Exciting Possibilities. N Engl J Med. 2021;384(1):1-4. doi:10.1056/NEJMp2030694

CBL mutations drive PI3K/AKT signaling via increased interaction with LYN and PIK3R1.

Belizaire R, Koochaki SHJ, Udeshi ND, et al. CBL mutations drive PI3K/AKT signaling via increased interaction with LYN and PIK3R1. Blood. 2021. doi:10.1182/blood.2020006528

Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma.

Huang C, Chen L, Savage SR, et al. Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma. Cancer Cell. 2021. doi:10.1016/j.ccell.2020.12.007