Publications

Streamlined inactivation, amplification, and Cas13-based detection of SARS-CoV-2.

Arizti-Sanz J, Freije CA, Stanton AC, et al. Streamlined inactivation, amplification, and Cas13-based detection of SARS-CoV-2. Nat Commun. 2020;11(1):5921. doi:10.1038/s41467-020-19097-x

Functional compensation precedes recovery of tissue mass following acute liver injury.

Walesky CM, Kolb KE, Winston CL, et al. Functional compensation precedes recovery of tissue mass following acute liver injury. Nat Commun. 2020;11(1):5785. doi:10.1038/s41467-020-19558-3

Detection of Pathogenic Variants With Germline Genetic Testing Using Deep Learning vs Standard Methods in Patients With Prostate Cancer and Melanoma.

AlDubayan SH, Conway JR, Camp SY, et al. Detection of Pathogenic Variants With Germline Genetic Testing Using Deep Learning vs Standard Methods in Patients With Prostate Cancer and Melanoma. JAMA. 2020;324(19):1957-1969. doi:10.1001/jama.2020.20457

A missense variant in confers risk for Crohn's disease by disrupting manganese homeostasis and intestinal barrier integrity.

Nakata T, Creasey EA, Kadoki M, et al. A missense variant in confers risk for Crohn’s disease by disrupting manganese homeostasis and intestinal barrier integrity. Proc Natl Acad Sci U S A. 2020;117(46):28930-28938. doi:10.1073/pnas.2014742117

A High-Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury.

Kost-Alimova M, Sidhom EH, Satyam A, et al. A High-Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury. Cell Rep Med. 2020;1(8):100137. doi:10.1016/j.xcrm.2020.100137

Identification of Natural CRISPR Systems and Targets in the Human Microbiome.

Münch PC, Franzosa EA, Stecher B, McHardy AC, Huttenhower C. Identification of Natural CRISPR Systems and Targets in the Human Microbiome. Cell Host Microbe. 2020. doi:10.1016/j.chom.2020.10.010

Acquired FGFR and FGF Alterations Confer Resistance to Estrogen Receptor (ER) Targeted Therapy in ER Metastatic Breast Cancer.

Mao P, Cohen O, Kowalski KJ, et al. Acquired FGFR and FGF Alterations Confer Resistance to Estrogen Receptor (ER) Targeted Therapy in ER Metastatic Breast Cancer. Clin Cancer Res. 2020;26(22):5974-5989. doi:10.1158/1078-0432.CCR-19-3958

Comprehensive characterization of amino acid positions in protein structures reveals molecular effect of missense variants.

Iqbal S, Pérez-Palma E, Jespersen JB, et al. Comprehensive characterization of amino acid positions in protein structures reveals molecular effect of missense variants. Proc Natl Acad Sci U S A. 2020;117(45):28201-28211. doi:10.1073/pnas.2002660117

A Systematic Protein Turnover Map for Decoding Protein Degradation.

Christiano R, Arlt H, Kabatnik S, et al. A Systematic Protein Turnover Map for Decoding Protein Degradation. Cell Rep. 2020;33(6):108378. doi:10.1016/j.celrep.2020.108378

TFEB Transcriptional Responses Reveal Negative Feedback by BHLHE40 and BHLHE41.

Carey KL, Paulus GLC, Wang L, et al. TFEB Transcriptional Responses Reveal Negative Feedback by BHLHE40 and BHLHE41. Cell Rep. 2020;33(6):108371. doi:10.1016/j.celrep.2020.108371

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Publications

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