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Publications

Genomic analyses of PMBL reveal new drivers and mechanisms of sensitivity to PD-1 blockade.

Chapuy B, Stewart C, Dunford AJ, et al. Genomic analyses of PMBL reveal new drivers and mechanisms of sensitivity to PD-1 blockade. Blood. 2019;134(26):2369-2382. doi:10.1182/blood.2019002067

Human Primordial Germ Cells Are Specified from Lineage-Primed Progenitors.

Chen D, Sun N, Hou L, et al. Human Primordial Germ Cells Are Specified from Lineage-Primed Progenitors. Cell Rep. 2019;29(13):4568-4582.e5. doi:10.1016/j.celrep.2019.11.083

Agreement between two large pan-cancer CRISPR-Cas9 gene dependency data sets.

Dempster JM, Pacini C, Pantel S, et al. Agreement between two large pan-cancer CRISPR-Cas9 gene dependency data sets. Nat Commun. 2019;10(1):5817. doi:10.1038/s41467-019-13805-y

Characterization of the Prion Protein Binding Properties of Antisense Oligonucleotides.

Reidenbach AG, Minikel EV, Zhao HT, et al. Characterization of the Prion Protein Binding Properties of Antisense Oligonucleotides. Biomolecules. 2019;10(1). doi:10.3390/biom10010001

In vitro selection predicts malaria parasite resistance to dihydroorotate dehydrogenase inhibitors in a mouse infection model.

Mandt REK, Lafuente-Monasterio MJ, Sakata-Kato T, et al. In vitro selection predicts malaria parasite resistance to dihydroorotate dehydrogenase inhibitors in a mouse infection model. Sci Transl Med. 2019;11(521). doi:10.1126/scitranslmed.aav1636

Activity-by-contact model of enhancer-promoter regulation from thousands of CRISPR perturbations.

Fulco CP, Nasser J, Jones TR, et al. Activity-by-contact model of enhancer-promoter regulation from thousands of CRISPR perturbations. Nat Genet. 2019;51(12):1664-1669. doi:10.1038/s41588-019-0538-0

Domain-specific Quantification of Prion Protein in Cerebrospinal Fluid by Targeted Mass Spectrometry.

Minikel EV, Kuhn E, Cocco AR, et al. Domain-specific Quantification of Prion Protein in Cerebrospinal Fluid by Targeted Mass Spectrometry. Mol Cell Proteomics. 2019;18(12):2388-2400. doi:10.1074/mcp.RA119.001702

Genomics and Targeted Therapies in Gastroesophageal Adenocarcinoma.

Nagaraja AK, Kikuchi O, Bass AJ. Genomics and Targeted Therapies in Gastroesophageal Adenocarcinoma. Cancer Discov. 2019;9(12):1656-1672. doi:10.1158/2159-8290.CD-19-0487

Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma.

Liu D, Schilling B, Liu D, et al. Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma. Nat Med. 2019;25(12):1916-1927. doi:10.1038/s41591-019-0654-5

Fibroblastic reticular cells enhance T cell metabolism and survival via epigenetic remodeling.

Brown FD, Sen DR, LaFleur MW, et al. Fibroblastic reticular cells enhance T cell metabolism and survival via epigenetic remodeling. Nat Immunol. 2019;20(12):1668-1680. doi:10.1038/s41590-019-0515-x