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Our Protein Technologies group encompasses the disciplines of protein science, structural biology, and the downstream applications of the RABIT platform for therapeutic development.

The group’s Protein Science sub-team possesses substantial expertise in:

• producing, purifying, and characterizing a broad array of proteins
• utilizing bacterial, insect, and mammalian expression systems
• Characterizing proteins using biophysical methods

The functionally characterized proteins the group produces form the basis of assays that drive the identification and optimization of lead compounds.

The Structural Biology sub-team employs X-ray crystallography and CryoEM techniques and robust pipelines to generate structural data that supports:

• drug discovery efforts 
• elucidation of protein structure-function relationships 
• structural biology analysis for base editing (BE) tiling screens

We maintain close collaboration with computational and medicinal chemists to facilitate: 

• structure-based design 
• analysis via molecular docking and dynamics 
• virtual/pharmacophore-based screening for novel chemical entities

In addition, the Protein Technologies group supports the RABIT platform by producing antigen proteins, isolating functional single chain binders utilizing cell-free or mammalian systems, and implementing innovative approaches to develop reagents or biological therapeutics, such as biparatopic antibodies.