Jain SU, Williamson KE, Ying AW, et al. A SWI/SNF-specific Ig-like domain, SWIFT, is a transcription factor binding platform. Science (New York, N.Y.). 2026:eaeb3627. doi:10.1126/science.aeb3627
Epigenomics
Liu Z, Zhang S, James BT, et al. Single-cell multiregion epigenomic rewiring in Alzheimer’s disease progression and cognitive resilience. Cell. 2025;188(18):4980-5002.e29. doi:10.1016/j.cell.2025.06.031
Hu Y, Horlbeck MA, Zhang R, et al. Multiscale footprints reveal the organization of cis-regulatory elements. Nature. 2025. doi:10.1038/s41586-024-08443-4
St Laurent JD, Xu GD, Ying AW, et al. Shifted assembly and function of mSWI/SNF family subcomplexes underlie targetable dependencies in dedifferentiated endometrial carcinomas. Nature genetics. 2025. doi:10.1038/s41588-025-02333-9
Ruff KM, King MR, Ying AW, et al. Molecular grammars of predicted intrinsically disordered regions that span the human proteome. Cell. 2025. doi:10.1016/j.cell.2025.10.019
Goel VY, Aboreden NG, Jusuf JM, et al. Dynamics of microcompartment formation at the mitosis-to-G1 transition. Nature structural & molecular biology. 2025. doi:10.1038/s41594-025-01687-2
DaSilva LF, Senan S, Kribelbauer-Swietek JF, et al. Designing synthetic regulatory elements using the generative AI framework DNA-Diffusion. Nature genetics. 2025. doi:10.1038/s41588-025-02441-6
Yang J, Wang C, Fu D, et al. Mature and migratory dendritic cells promote immune infiltration and response to anti-PD-1 checkpoint blockade in metastatic melanoma. Nature communications. 2025;16(1):8151. doi:10.1038/s41467-025-62878-5
Roseman SA, Siegenfeld AP, Lee C, Lue NZ, Waterbury AL, Liau BB. DNA methylation insulates genic regions from CTCF loops near nuclear speckles. eLife. 2025;13. doi:10.7554/eLife.102930
Steinicke TL, Benfatto S, Capilla-Guerra MR, et al. Rapid epigenomic classification of acute leukemia. Nature genetics. 2025. doi:10.1038/s41588-025-02321-z