Kartha V, Duarte F, Hu Y, et al. Functional inference of gene regulation using single-cell multi-omics. Cell genomics. 2022;2(9). doi:10.1016/j.xgen.2022.100166
Epigenomics
Miller T, Lareau C, Verga J, et al. Mitochondrial variant enrichment from high-throughput single-cell RNA sequencing resolves clonal populations. Nature biotechnology. 2022;40(7):1030-1034. doi:10.1038/s41587-022-01210-8
Vlaming H, Mimoso C, Field A, Martin B, Adelman K. Screening thousands of transcribed coding and non-coding regions reveals sequence determinants of RNA polymerase II elongation potential. Nature structural & molecular biology. 2022;29(6):613-620. doi:10.1038/s41594-022-00785-9
Uzquiano A, Kedaigle AJ, Pigoni M, et al. Proper acquisition of cell class identity in organoids allows definition of fate specification programs of the human cerebral cortex. Cell. 2022;185(20):3770-3788.e27. doi:10.1016/j.cell.2022.09.010
Tognon M, Bonnici V, Garrison E, Giugno R, Pinello L. GRAFIMO: Variant and haplotype aware motif scanning on pangenome graphs. PLoS computational biology. 2021;17(9):e1009444. doi:10.1371/journal.pcbi.1009444
de Goede O. Population-scale tissue transcriptomics maps long non-coding RNAs to complex disease. Cell. 2021;184(10):2633-2648.e19. doi:10.1016/j.cell.2021.03.050
Kim-Hellmuth S. Cell type-specific genetic regulation of gene expression across human tissues. Science (New York, N.Y.). 2020;369(6509). doi:10.1126/science.aaz8528
Ma S. Chromatin Potential Identified by Shared Single-Cell Profiling of RNA and Chromatin. Cell. 2020;183(4):1103-1116.e20. doi:10.1016/j.cell.2020.09.056
Vinyard ME, Su C, Siegenfeld AP, et al. CRISPR-suppressor scanning reveals a nonenzymatic role of LSD1 in AML. Nat Chem Biol. 2019;15(5):529-539. doi:10.1038/s41589-019-0263-0
Choi J, Huebner AJ, Clement K, et al. Prolonged Mek1/2 suppression impairs the developmental potential of embryonic stem cells. Nature. 2017;548(7666):219-223. doi:10.1038/nature23274