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Epigenomics

Cell type-specific genetic regulation of gene expression across human tissues.

Kim-Hellmuth S. Cell type-specific genetic regulation of gene expression across human tissues. Science (New York, N.Y.). 2020;369(6509). doi:10.1126/science.aaz8528

Chromatin Potential Identified by Shared Single-Cell Profiling of RNA and Chromatin.

Ma S. Chromatin Potential Identified by Shared Single-Cell Profiling of RNA and Chromatin. Cell. 2020;183(4):1103-1116.e20. doi:10.1016/j.cell.2020.09.056

CRISPR-suppressor scanning reveals a nonenzymatic role of LSD1 in AML.

Vinyard ME, Su C, Siegenfeld AP, et al. CRISPR-suppressor scanning reveals a nonenzymatic role of LSD1 in AML. Nat Chem Biol. 2019;15(5):529-539. doi:10.1038/s41589-019-0263-0

Prolonged Mek1/2 suppression impairs the developmental potential of embryonic stem cells.

Choi J, Huebner AJ, Clement K, et al. Prolonged Mek1/2 suppression impairs the developmental potential of embryonic stem cells. Nature. 2017;548(7666):219-223. doi:10.1038/nature23274

A Genetic Variant Associated with Five Vascular Diseases Is a Distal Regulator of Endothelin-1 Gene Expression.

Gupta RM, Hadaya J, Trehan A, et al. A Genetic Variant Associated with Five Vascular Diseases Is a Distal Regulator of Endothelin-1 Gene Expression. Cell. 2017;170(3):522-533.e15. doi:10.1016/j.cell.2017.06.049

DUSP9 Modulates DNA Hypomethylation in Female Mouse Pluripotent Stem Cells.

Choi J, Clement K, Huebner AJ, et al. DUSP9 Modulates DNA Hypomethylation in Female Mouse Pluripotent Stem Cells. Cell Stem Cell. 2017;20(5):706-719.e7. doi:10.1016/j.stem.2017.03.002

Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease.

Warren CR, O’Sullivan JF, Friesen M, et al. Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease. Cell Stem Cell. 2017;20(4):547-557.e7. doi:10.1016/j.stem.2017.01.010

Epigenetic Memory Underlies Cell-Autonomous Heterogeneous Behavior of Hematopoietic Stem Cells.

Yu VWC, Yusuf RZ, Oki T, et al. Epigenetic Memory Underlies Cell-Autonomous Heterogeneous Behavior of Hematopoietic Stem Cells. Cell. 2016;167(5):1310-1322.e17. doi:10.1016/j.cell.2016.10.045

Discovery and validation of sub-threshold genome-wide association study loci using epigenomic signatures.

Wang X, Tucker NR, Rizki G, et al. Discovery and validation of sub-threshold genome-wide association study loci using epigenomic signatures. Elife. 2016;5. doi:10.7554/eLife.10557

Single-molecule decoding of combinatorially modified nucleosomes.

Shema E, Jones D, Shoresh N, Donohue L, Ram O, Bernstein BE. Single-molecule decoding of combinatorially modified nucleosomes. Science. 2016;352(6286):717-21. doi:10.1126/science.aad7701