Cancellieri S, Zeng J, Lin L, et al. Human genetic diversity alters off-target outcomes of therapeutic gene editing. Nature genetics. 2023;55(1):34-43. doi:10.1038/s41588-022-01257-y
Epigenomics
Lue NZ, Garcia EM, Ngan K, Lee C, Doench JG, Liau BB. Base editor scanning charts the DNMT3A activity landscape. Nature chemical biology. 2023;19(2):176-186. doi:10.1038/s41589-022-01167-4
Battaglia S, Dong K, Wu J, et al. Long-range phasing of dynamic, tissue-specific and allele-specific regulatory elements. Nat Genet. 2022;54(10):1504-1513. doi:10.1038/s41588-022-01188-8
Glinos DA, Garborcauskas G, Hoffman P, et al. Transcriptome variation in human tissues revealed by long-read sequencing. Nature. 2022. doi:10.1038/s41586-022-05035-y
Gabriele M, Brandão HB, Grosse-Holz S, et al. Dynamics of CTCF- and cohesin-mediated chromatin looping revealed by live-cell imaging. Science. 2022:eabn6583. doi:10.1126/science.abn6583
Miller T, Lareau C, Verga J, et al. Mitochondrial variant enrichment from high-throughput single-cell RNA sequencing resolves clonal populations. Nature biotechnology. 2022;40(7):1030-1034. doi:10.1038/s41587-022-01210-8
Johnstone S, Gladyshev V, Aryee M, Bernstein B. Epigenetic clocks, aging, and cancer. Science (New York, N.Y.). 2022;378(6626):1276-1277. doi:10.1126/science.abn4009
Kartha V, Duarte F, Hu Y, et al. Functional inference of gene regulation using single-cell multi-omics. Cell genomics. 2022;2(9). doi:10.1016/j.xgen.2022.100166
Vlaming H, Mimoso C, Field A, Martin B, Adelman K. Screening thousands of transcribed coding and non-coding regions reveals sequence determinants of RNA polymerase II elongation potential. Nature structural & molecular biology. 2022;29(6):613-620. doi:10.1038/s41594-022-00785-9
Zhao T, Chiang ZD, Morriss JW, et al. Spatial genomics enables multi-modal study of clonal heterogeneity in tissues. Nature. 2022;601(7891):85-91. doi:10.1038/s41586-021-04217-4