Glinos DA, Garborcauskas G, Hoffman P, et al. Transcriptome variation in human tissues revealed by long-read sequencing. Nature. 2022. doi:10.1038/s41586-022-05035-y
Epigenomics
Gabriele M, Brandão HB, Grosse-Holz S, et al. Dynamics of CTCF- and cohesin-mediated chromatin looping revealed by live-cell imaging. Science. 2022:eabn6583. doi:10.1126/science.abn6583
Johnstone S, Gladyshev V, Aryee M, Bernstein B. Epigenetic clocks, aging, and cancer. Science (New York, N.Y.). 2022;378(6626):1276-1277. doi:10.1126/science.abn4009
Miller T, Lareau C, Verga J, et al. Mitochondrial variant enrichment from high-throughput single-cell RNA sequencing resolves clonal populations. Nature biotechnology. 2022;40(7):1030-1034. doi:10.1038/s41587-022-01210-8
Vlaming H, Mimoso C, Field A, Martin B, Adelman K. Screening thousands of transcribed coding and non-coding regions reveals sequence determinants of RNA polymerase II elongation potential. Nature structural & molecular biology. 2022;29(6):613-620. doi:10.1038/s41594-022-00785-9
Zhao T, Chiang ZD, Morriss JW, et al. Spatial genomics enables multi-modal study of clonal heterogeneity in tissues. Nature. 2022;601(7891):85-91. doi:10.1038/s41586-021-04217-4
Uzquiano A, Kedaigle AJ, Pigoni M, et al. Proper acquisition of cell class identity in organoids allows definition of fate specification programs of the human cerebral cortex. Cell. 2022;185(20):3770-3788.e27. doi:10.1016/j.cell.2022.09.010
Kartha V, Duarte F, Hu Y, et al. Functional inference of gene regulation using single-cell multi-omics. Cell genomics. 2022;2(9). doi:10.1016/j.xgen.2022.100166
Tognon M, Bonnici V, Garrison E, Giugno R, Pinello L. GRAFIMO: Variant and haplotype aware motif scanning on pangenome graphs. PLoS computational biology. 2021;17(9):e1009444. doi:10.1371/journal.pcbi.1009444
de Goede O. Population-scale tissue transcriptomics maps long non-coding RNAs to complex disease. Cell. 2021;184(10):2633-2648.e19. doi:10.1016/j.cell.2021.03.050