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Metabolomics Platform

Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors.

Dong CK, Urgaonkar S, Cortese JF, et al. Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors. Chem Biol. 2011;18(12):1602-10. doi:10.1016/j.chembiol.2011.09.016

A haploid genetic screen identifies the major facilitator domain containing 2A (MFSD2A) transporter as a key mediator in the response to tunicamycin.

Reiling JH, Clish CB, Carette JE, Varadarajan M, Brummelkamp TR, Sabatini DM. A haploid genetic screen identifies the major facilitator domain containing 2A (MFSD2A) transporter as a key mediator in the response to tunicamycin. Proc Natl Acad Sci U S A. 2011;108(29):11756-65. doi:10.1073/pnas.1018098108

A hypoxia-induced positive feedback loop promotes hypoxia-inducible factor 1alpha stability through miR-210 suppression of glycerol-3-phosphate dehydrogenase 1-like.

Kelly TJ, Souza AL, Clish CB, Puigserver P. A hypoxia-induced positive feedback loop promotes hypoxia-inducible factor 1alpha stability through miR-210 suppression of glycerol-3-phosphate dehydrogenase 1-like. Mol Cell Biol. 2011;31(13):2696-706. doi:10.1128/MCB.01242-10

Metabolite profiles and the risk of developing diabetes.

Wang TJ, Larson MG, Vasan RS, et al. Metabolite profiles and the risk of developing diabetes. Nat Med. 2011;17(4):448-53. doi:10.1038/nm.2307

Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans.

Rhee EP, Cheng S, Larson MG, et al. Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans. J Clin Invest. 2011;121(4):1402-11. doi:10.1172/JCI44442

SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization.

Finley LWS, Carracedo A, Lee J, et al. SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization. Cancer Cell. 2011;19(3):416-28. doi:10.1016/j.ccr.2011.02.014

Induction of erythroid differentiation in human erythroleukemia cells by depletion of malic enzyme 2.

Ren JG, Seth P, Everett P, Clish CB, Sukhatme VP. Induction of erythroid differentiation in human erythroleukemia cells by depletion of malic enzyme 2. PLoS One. 2010;5(9). doi:10.1371/journal.pone.0012520

Activation of a metabolic gene regulatory network downstream of mTOR complex 1.

Düvel K, Yecies JL, Menon S, et al. Activation of a metabolic gene regulatory network downstream of mTOR complex 1. Mol Cell. 2010;39(2):171-83. doi:10.1016/j.molcel.2010.06.022

Metabolite profiling identifies markers of uremia.

Rhee EP, Souza A, Farrell L, et al. Metabolite profiling identifies markers of uremia. J Am Soc Nephrol. 2010;21(6):1041-1051. doi:10.1681/ASN.2009111132

Metabolic signatures of exercise in human plasma.

Lewis GD, Farrell L, Wood MJ, et al. Metabolic signatures of exercise in human plasma. Sci Transl Med. 2010;2(33):33ra37. doi:10.1126/scitranslmed.3001006