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Proteomics Platform

The conserved translation factor LepA is required for optimal synthesis of a porin family in .

Fishbein SRS, Tomasi FG, Wolf ID, et al. The conserved translation factor LepA is required for optimal synthesis of a porin family in . J Bacteriol. 2020. doi:10.1128/JB.00604-20

Cohesin mutations alter DNA damage repair and chromatin structure and create therapeutic vulnerabilities in MDS/AML.

Tothova Z, Valton AL, Gorelov R, et al. Cohesin mutations alter DNA damage repair and chromatin structure and create therapeutic vulnerabilities in MDS/AML. JCI Insight. 2020. doi:10.1172/jci.insight.142149

The SARS-CoV-2 RNA-protein interactome in infected human cells.

Schmidt N, Lareau CA, Keshishian H, et al. The SARS-CoV-2 RNA-protein interactome in infected human cells. Nat Microbiol. 2020. doi:10.1038/s41564-020-00846-z

Avant-garde: an automated data-driven DIA data curation tool.

Jacome AS, Peckner R, Shulman N, et al. Avant-garde: an automated data-driven DIA data curation tool. Nat Methods. 2020;17(12):1237-1244. doi:10.1038/s41592-020-00986-4

Proximity labeling in mammalian cells with TurboID and split-TurboID.

Cho KF, Branon TC, Udeshi ND, Myers SA, Carr SA, Ting AY. Proximity labeling in mammalian cells with TurboID and split-TurboID. Nat Protoc. 2020;15(12):3971-3999. doi:10.1038/s41596-020-0399-0

Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy.

Krug K, Jaehnig EJ, Satpathy S, et al. Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy. Cell. 2020;183(5):1436-1456.e31. doi:10.1016/j.cell.2020.10.036

SARS-CoV-2 infected cells present HLA-I peptides from canonical and out-of-frame ORFs.

Weingarten-Gabbay S, Klaeger S, Sarkizova S, et al. SARS-CoV-2 infected cells present HLA-I peptides from canonical and out-of-frame ORFs. bioRxiv. 2020. doi:10.1101/2020.10.02.324145

BRG1 Loss Predisposes Lung Cancers to Replicative Stress and ATR Dependency.

Gupta M, Concepcion CP, Fahey CG, et al. BRG1 Loss Predisposes Lung Cancers to Replicative Stress and ATR Dependency. Cancer Res. 2020;80(18):3841-3854. doi:10.1158/0008-5472.CAN-20-1744

RNA-protein interaction mapping via MS2- or Cas13-based APEX targeting.

Han S, Zhao BS, Myers SA, Carr SA, He C, Ting AY. RNA-protein interaction mapping via MS2- or Cas13-based APEX targeting. Proc Natl Acad Sci U S A. 2020;117(36):22068-22079. doi:10.1073/pnas.2006617117

CITED4 Protects Against Adverse Remodeling in Response to Physiological and Pathological Stress.

Lerchenmüller C, Rabolli CP, Yeri A, et al. CITED4 Protects Against Adverse Remodeling in Response to Physiological and Pathological Stress. Circ Res. 2020;127(5):631-646. doi:10.1161/CIRCRESAHA.119.315881