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Proteomics Platform

Patterns of substrate affinity, competition, and degradation kinetics underlie biological activity of thalidomide analogs.

Sperling AS, Burgess M, Keshishian H, et al. Patterns of substrate affinity, competition, and degradation kinetics underlie biological activity of thalidomide analogs. Blood. 2019;134(2):160-170. doi:10.1182/blood.2019000789

TMT Labeling for the Masses: A Robust and Cost-efficient, In-solution Labeling Approach.

Zecha J, Satpathy S, Kanashova T, et al. TMT Labeling for the Masses: A Robust and Cost-efficient, In-solution Labeling Approach. Mol Cell Proteomics. 2019;18(7):1468-1478. doi:10.1074/mcp.TIR119.001385

Regulated Phosphosignaling Associated with Breast Cancer Subtypes and Druggability.

Huang K lin, Wu Y, Primeau T, et al. Regulated Phosphosignaling Associated with Breast Cancer Subtypes and Druggability. Mol Cell Proteomics. 2019. doi:10.1074/mcp.RA118.001243

Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma.

Bandopadhayay P, Piccioni F, O’Rourke R, et al. Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma. Nat Commun. 2019;10(1):2400. doi:10.1038/s41467-019-10307-9

Streamlined Protocol for Deep Proteomic Profiling of FAC-sorted Cells and Its Application to Freshly Isolated Murine Immune Cells.

Myers SA, Rhoads A, Cocco AR, et al. Streamlined Protocol for Deep Proteomic Profiling of FAC-sorted Cells and Its Application to Freshly Isolated Murine Immune Cells. Mol Cell Proteomics. 2019;18(5):995-1009. doi:10.1074/mcp.RA118.001259

Trio Haploinsufficiency Causes Neurodevelopmental Disease-Associated Deficits.

Katrancha SM, Shaw JE, Zhao AY, et al. Trio Haploinsufficiency Causes Neurodevelopmental Disease-Associated Deficits. Cell Rep. 2019;26(10):2805-2817.e9. doi:10.1016/j.celrep.2019.02.022

A Curated Resource for Phosphosite-specific Signature Analysis.

Krug K, Mertins P, Zhang B, et al. A Curated Resource for Phosphosite-specific Signature Analysis. Mol Cell Proteomics. 2019;18(3):576-593. doi:10.1074/mcp.TIR118.000943

In Situ Peroxidase Labeling and Mass Spectrometry of Alpha-Synuclein in Rat Cortical Neurons.

Sanz R, Ovando-Roche P, Udeshi ND, Carr SA, Chung CY, Khurana V. In Situ Peroxidase Labeling and Mass Spectrometry of Alpha-Synuclein in Rat Cortical Neurons. Methods Mol Biol. 2019;1948:235-246. doi:10.1007/978-1-4939-9124-2_18

Tetracyclines Modify Translation by Targeting Key Human rRNA Substructures.

Mortison JD, Schenone M, Myers JA, et al. Tetracyclines Modify Translation by Targeting Key Human rRNA Substructures. Cell Chem Biol. 2018;25(12):1506-1518.e13. doi:10.1016/j.chembiol.2018.09.010

Evaluation of Advanced Precursor Determination for Tandem Mass Tag (TMT)-Based Quantitative Proteomics across Instrument Platforms.

Myers SA, Klaeger S, Satpathy S, et al. Evaluation of Advanced Precursor Determination for Tandem Mass Tag (TMT)-Based Quantitative Proteomics across Instrument Platforms. J Proteome Res. 2018. doi:10.1021/acs.jproteome.8b00611