ӳ��ý

Eric Lander

Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations.

1.

Khera AV, Chaffin M, Aragam KG, et al. Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations. Nat Genet. 2018;50(9):1219-1224. doi:10.1038/s41588-018-0183-z.

The NORAD lncRNA assembles a topoisomerase complex critical for genome stability.

1.

Munschauer M, Nguyen CT, Sirokman K, et al. The NORAD lncRNA assembles a topoisomerase complex critical for genome stability. Nature. 2018;561(7721):132-136. doi:10.1038/s41586-018-0453-z.

Deep-coverage whole genome sequences and blood lipids among 16,324 individuals.

1.

Natarajan P, Peloso GM, Zekavat SM, et al. Deep-coverage whole genome sequences and blood lipids among 16,324 individuals. Nat Commun. 2018;9(1):3391. doi:10.1038/s41467-018-05747-8.

Positional specificity of different transcription factor classes within enhancers.

1.

Grossman SR, Engreitz J, Ray JP, Nguyen TH, Hacohen N, Lander ES. Positional specificity of different transcription factor classes within enhancers. Proc Natl Acad Sci U S A. 2018;115(30):E7222-E7230. doi:10.1073/pnas.1804663115.

Strain-Level Analysis of Mother-to-Child Bacterial Transmission during the First Few Months of Life.

1.

Yassour M, Jason E, Hogstrom LJ, et al. Strain-Level Analysis of Mother-to-Child Bacterial Transmission during the First Few Months of Life. Cell Host Microbe. 2018;24(1):146-154.e4. doi:10.1016/j.chom.2018.06.007.

Ribosome Levels Selectively Regulate Translation and Lineage Commitment in Human Hematopoiesis.

1.

Khajuria RK, Munschauer M, Ulirsch JC, et al. Ribosome Levels Selectively Regulate Translation and Lineage Commitment in Human Hematopoiesis. Cell. 2018;173(1):90-103.e19. doi:10.1016/j.cell.2018.02.036.

Genetic mechanisms of immune evasion in colorectal cancer.

1.

Grasso CS, Giannakis M, Wells DK, et al. Genetic mechanisms of immune evasion in colorectal cancer. Cancer Discov. 2018. doi:10.1158/2159-8290.CD-17-1327.

Direct Identification of Hundreds of Expression-Modulating Variants using a Multiplexed Reporter Assay.

1.

Tewhey R, Kotliar D, Park DS, et al. Direct Identification of Hundreds of Expression-Modulating Variants using a Multiplexed Reporter Assay. Cell. 2018;172(5):1132-1134. doi:10.1016/j.cell.2018.02.021.

Sequence data and association statistics from 12,940 type 2 diabetes cases and controls.

1.

Flannick J, Fuchsberger C, Mahajan A, et al. Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. Sci Data. 2017;4:170179. doi:10.1038/sdata.2017.179.

A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models.

1.

Zhou Y, Castonguay P, Sidhom E-H, et al. A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models. Science. 2017;358(6368):1332-1336. doi:10.1126/science.aal4178.