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Eric Lander

Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms.

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Rusu V, Hoch E, Mercader JM, et al. Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms. Cell. 2017;170(1):199-212.e20. doi:10.1016/j.cell.2017.06.011.

Protein-Truncating Variants at the Cholesteryl Ester Transfer Protein Gene and Risk for Coronary Heart Disease.

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Nomura A, Won H-H, Khera AV, et al. Protein-Truncating Variants at the Cholesteryl Ester Transfer Protein Gene and Risk for Coronary Heart Disease. Circ Res. 2017;121(1):81-88. doi:10.1161/CIRCRESAHA.117.311145.

Improved imputation accuracy of rare and low-frequency variants using population-specific high-coverage WGS-based imputation reference panel.

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Mitt M, Kals M, Pärn K, et al. Improved imputation accuracy of rare and low-frequency variants using population-specific high-coverage WGS-based imputation reference panel. Eur J Hum Genet. 2017;25(7):869-876. doi:10.1038/ejhg.2017.51.

ANGPTL3 Deficiency and Protection Against Coronary Artery Disease.

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Stitziel NO, Khera AV, Wang X, et al. ANGPTL3 Deficiency and Protection Against Coronary Artery Disease. J Am Coll Cardiol. 2017;69(16):2054-2063. doi:10.1016/j.jacc.2017.02.030.

Human knockouts and phenotypic analysis in a cohort with a high rate of consanguinity.

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Saleheen D, Natarajan P, Armean IM, et al. Human knockouts and phenotypic analysis in a cohort with a high rate of consanguinity. Nature. 2017;544(7649):235-239. doi:10.1038/nature22034.

De novo assembly of the Aedes aegypti genome using Hi-C yields chromosome-length scaffolds.

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Dudchenko O, Batra SS, Omer AD, et al. De novo assembly of the Aedes aegypti genome using Hi-C yields chromosome-length scaffolds. Science. 2017;356(6333):92-95. doi:10.1126/science.aal3327.

Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation.

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Kim AR, Ulirsch JC, Wilmes S, et al. Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation. Cell. 2017;168(6):1053-1064.e15. doi:10.1016/j.cell.2017.02.026.

Association of Rare and Common Variation in the Lipoprotein Lipase Gene With Coronary Artery Disease.

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Khera AV, Won H-H, Peloso GM, et al. Association of Rare and Common Variation in the Lipoprotein Lipase Gene With Coronary Artery Disease. JAMA. 2017;317(9):937-946. doi:10.1001/jama.2017.0972.

Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras.

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Wang T, Yu H, Hughes NW, et al. Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras. Cell. 2017;168(5):890-903.e15. doi:10.1016/j.cell.2017.01.013.

Systematic dissection of genomic features determining transcription factor binding and enhancer function.

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Grossman SR, Zhang X, Wang L, et al. Systematic dissection of genomic features determining transcription factor binding and enhancer function. Proc Natl Acad Sci U S A. 2017;114(7):E1291-E1300. doi:10.1073/pnas.1621150114.