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Eric Lander

Systematic dissection of genomic features determining transcription factor binding and enhancer function.

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Grossman SR, Zhang X, Wang L, et al. Systematic dissection of genomic features determining transcription factor binding and enhancer function. Proc Natl Acad Sci U S A. 2017;114(7):E1291-E1300. doi:10.1073/pnas.1621150114.

A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors.

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Park RJ, Wang T, Koundakjian D, et al. A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors. Nat Genet. 2017;49(2):193-203. doi:10.1038/ng.3741.

Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms.

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Guo MH, Nandakumar SK, Ulirsch JC, et al. Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms. Proc Natl Acad Sci U S A. 2017;114(3):E327-E336. doi:10.1073/pnas.1619052114.

Integrated genomic characterization of oesophageal carcinoma.

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Cancer Genome Atlas Research Network, Analysis Working Group: Asan University, BC Cancer Agency, et al. Integrated genomic characterization of oesophageal carcinoma. Nature. 2017;541(7636):169-175. doi:10.1038/nature20805.

Phenotypic Characterization of Genetically Lowered Human Lipoprotein(a) Levels.

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Emdin CA, Khera AV, Natarajan P, et al. Phenotypic Characterization of Genetically Lowered Human Lipoprotein(a) Levels. J Am Coll Cardiol. 2016;68(25):2761-2772. doi:10.1016/j.jacc.2016.10.033.

Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens.

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Dixit A, Parnas O, Li B, et al. Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens. Cell. 2016;167(7):1853-1866.e17. doi:10.1016/j.cell.2016.11.038.

Systematic mapping of functional enhancer-promoter connections with CRISPR interference.

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Fulco CP, Munschauer M, Anyoha R, et al. Systematic mapping of functional enhancer-promoter connections with CRISPR interference. Science. 2016;354(6313):769-773. doi:10.1126/science.aag2445.

C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector.

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Abudayyeh OO, Gootenberg JS, Konermann S, et al. C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector. Science. 2016;353(6299):aaf5573. doi:10.1126/science.aaf5573.

The genetic architecture of type 2 diabetes.

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Fuchsberger C, Flannick J, Teslovich TM, et al. The genetic architecture of type 2 diabetes. Nature. 2016;536(7614):41-7. doi:10.1038/nature18642.

Deletion of DXZ4 on the human inactive X chromosome alters higher-order genome architecture.

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Darrow EM, Huntley MH, Dudchenko O, et al. Deletion of DXZ4 on the human inactive X chromosome alters higher-order genome architecture. Proc Natl Acad Sci U S A. 2016;113(31):E4504-12. doi:10.1073/pnas.1609643113.