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Eric Lander

Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing.

1.

Imielinski M, Berger AH, Hammerman PS, et al. Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing. Cell. 2012;150(6):1107-20. doi:10.1016/j.cell.2012.08.029.

A landscape of driver mutations in melanoma.

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Hodis E, Watson IR, Kryukov GV, et al. A landscape of driver mutations in melanoma. Cell. 2012;150(2):251-63. doi:10.1016/j.cell.2012.06.024.

Exome sequencing identifies GATA1 mutations resulting in Diamond-Blackfan anemia.

1.

Sankaran VG, Ghazvinian R, Do R, et al. Exome sequencing identifies GATA1 mutations resulting in Diamond-Blackfan anemia. J Clin Invest. 2012;122(7):2439-43. doi:10.1172/JCI63597.

Sequence analysis of mutations and translocations across breast cancer subtypes.

1.

Banerji S, Cibulskis K, Rangel-Escareño C, et al. Sequence analysis of mutations and translocations across breast cancer subtypes. Nature. 2012;486(7403):405-9. doi:10.1038/nature11154.

Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer.

1.

Barbieri CE, Baca SC, Lawrence MS, et al. Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer. Nat Genet. 2012;44(6):685-9. doi:10.1038/ng.2279.

Identification of a selective small molecule inhibitor of breast cancer stem cells.

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Germain AR, Carmody LC, Morgan B, et al. Identification of a selective small molecule inhibitor of breast cancer stem cells. Bioorg Med Chem Lett. 2012;22(10):3571-4. doi:10.1016/j.bmcl.2012.01.035.

Melanoma genome sequencing reveals frequent PREX2 mutations.

1.

Berger MF, Hodis E, Heffernan TP, et al. Melanoma genome sequencing reveals frequent PREX2 mutations. Nature. 2012;485(7399):502-6. doi:10.1038/nature11071.

Absolute quantification of somatic DNA alterations in human cancer.

1.

Carter SL, Cibulskis K, Helman E, et al. Absolute quantification of somatic DNA alterations in human cancer. Nat Biotechnol. 2012;30(5):413-21. doi:10.1038/nbt.2203.

The genomic basis of adaptive evolution in threespine sticklebacks.

1.

Jones FC, Grabherr MG, Chan YF, et al. The genomic basis of adaptive evolution in threespine sticklebacks. Nature. 2012;484(7392):55-61. doi:10.1038/nature10944.

Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing.

1.

Lohr JG, Stojanov P, Lawrence MS, et al. Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing. Proc Natl Acad Sci U S A. 2012;109(10):3879-84. doi:10.1073/pnas.1121343109.