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Eric Lander

Activating mTOR mutations in a patient with an extraordinary response on a phase I trial of everolimus and pazopanib.

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Wagle N, Grabiner BC, Van Allen EM, et al. Activating mTOR mutations in a patient with an extraordinary response on a phase I trial of everolimus and pazopanib. Cancer Discov. 2014;4(5):546-53. doi:10.1158/2159-8290.CD-13-0353.

A polygenic burden of rare disruptive mutations in schizophrenia.

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Purcell SM, Moran JL, Fromer M, et al. A polygenic burden of rare disruptive mutations in schizophrenia. Nature. 2014;506(7487):185-90. doi:10.1038/nature12975.

Topological organization of multichromosomal regions by the long intergenic noncoding RNA Firre.

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Hacisuleyman E, Goff LA, Trapnell C, et al. Topological organization of multichromosomal regions by the long intergenic noncoding RNA Firre. Nat Struct Mol Biol. 2014;21(2):198-206. doi:10.1038/nsmb.2764.

Searching for missing heritability: designing rare variant association studies.

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Zuk O, Schaffner SF, Samocha K, et al. Searching for missing heritability: designing rare variant association studies. Proc Natl Acad Sci U S A. 2014;111(4):E455-64. doi:10.1073/pnas.1322563111.

Discovery and saturation analysis of cancer genes across 21 tumour types.

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Lawrence MS, Stojanov P, Mermel CH, et al. Discovery and saturation analysis of cancer genes across 21 tumour types. Nature. 2014;505(7484):495-501. doi:10.1038/nature12912.

Genetic screens in human cells using the CRISPR-Cas9 system.

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Wang T, Wei JJ, Sabatini DM, Lander ES. Genetic screens in human cells using the CRISPR-Cas9 system. Science. 2014;343(6166):80-4. doi:10.1126/science.1246981.

Integrating sequence and array data to create an improved 1000 Genomes Project haplotype reference panel.

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Delaneau O, Marchini J, 1000 Genomes Project Consortium, 1000 Genomes Project Consortium. Integrating sequence and array data to create an improved 1000 Genomes Project haplotype reference panel. Nat Commun. 2014;5:3934. doi:10.1038/ncomms4934.

Colon cancer-derived oncogenic EGFR G724S mutant identified by whole genome sequence analysis is dependent on asymmetric dimerization and sensitive to cetuximab.

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Cho J, Bass AJ, Lawrence MS, et al. Colon cancer-derived oncogenic EGFR G724S mutant identified by whole genome sequence analysis is dependent on asymmetric dimerization and sensitive to cetuximab. Mol Cancer. 2014;13:141. doi:10.1186/1476-4598-13-141.

An improved canine genome and a comprehensive catalogue of coding genes and non-coding transcripts.

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Hoeppner MP, Lundquist A, Pirun M, et al. An improved canine genome and a comprehensive catalogue of coding genes and non-coding transcripts. PLoS One. 2014;9(3):e91172. doi:10.1371/journal.pone.0091172.

Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B.

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Karlsson EK, Sigurdsson S, Ivansson E, et al. Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B. Genome Biol. 2013;14(12):R132. doi:10.1186/gb-2013-14-12-r132.