Transcriptome-wide mapping reveals widespread dynamic-regulated pseudouridylation of ncRNA and mRNA. 1.Schwartz S, Bernstein DA, Mumbach MR, et al. Transcriptome-wide mapping reveals widespread dynamic-regulated pseudouridylation of ncRNA and mRNA. Cell. 2014;159(1):148-62. doi:10.1016/j.cell.2014.08.028. Read more
The genomic substrate for adaptive radiation in African cichlid fish. 1.Brawand D, Wagner CE, Li YI, et al. The genomic substrate for adaptive radiation in African cichlid fish. Nature. 2014;513(7518):375-81. doi:10.1038/nature13726. Read more
Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak. 1.Gire SK, Goba A, Andersen KG, et al. Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak. Science. 2014;345(6202):1369-72. doi:10.1126/science.1259657. Read more
Rabbit genome analysis reveals a polygenic basis for phenotypic change during domestication. 1.Carneiro M, Rubin C-J, di Palma F, et al. Rabbit genome analysis reveals a polygenic basis for phenotypic change during domestication. Science. 2014;345(6200):1074-9. doi:10.1126/science.1253714. Read more
Somatic mutation as a mechanism of Wnt/β-catenin pathway activation in CLL. 1.Wang L, Shalek AK, Lawrence M, et al. Somatic mutation as a mechanism of Wnt/β-catenin pathway activation in CLL. Blood. 2014;124(7):1089-98. doi:10.1182/blood-2014-01-552067. Read more
Systematic identification of personal tumor-specific neoantigens in chronic lymphocytic leukemia. 1.Rajasagi M, Shukla SA, Fritsch EF, et al. Systematic identification of personal tumor-specific neoantigens in chronic lymphocytic leukemia. Blood. 2014;124(3):453-62. doi:10.1182/blood-2014-04-567933. Read more
Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites. 1.Schwartz S, Mumbach MR, Jovanovic M, et al. Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5’ sites. Cell Rep. 2014;8(1):284-96. doi:10.1016/j.celrep.2014.05.048. Read more
Altered translation of GATA1 in Diamond-Blackfan anemia. 1.Ludwig LS, Gazda HT, Eng JC, et al. Altered translation of GATA1 in Diamond-Blackfan anemia. Nat Med. 2014;20(7):748-53. doi:10.1038/nm.3557. Read more
Development and applications of CRISPR-Cas9 for genome engineering. 1.Hsu PD, Lander ES, Zhang F. Development and applications of CRISPR-Cas9 for genome engineering. Cell. 2014;157(6):1262-78. doi:10.1016/j.cell.2014.05.010. Read more
Whole-exome sequencing and clinical interpretation of formalin-fixed, paraffin-embedded tumor samples to guide precision cancer medicine. 1.Van Allen EM, Wagle N, Stojanov P, et al. Whole-exome sequencing and clinical interpretation of formalin-fixed, paraffin-embedded tumor samples to guide precision cancer medicine. Nat Med. 2014;20(6):682-8. doi:10.1038/nm.3559. Read more