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Publications

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.

Rosenbluh J, Mercer J, Shrestha Y, et al. Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers. Cell Syst. 2016;3(3):302-316.e4. doi:10.1016/j.cels.2016.09.001

52 Genetic Loci Influencing Myocardial Mass.

van der Harst P, van Setten J, Verweij N, et al. 52 Genetic Loci Influencing Myocardial Mass. J Am Coll Cardiol. 2016;68(13):1435-48. doi:10.1016/j.jacc.2016.07.729

Morphometricity as a measure of the neuroanatomical signature of a trait.

Sabuncu MR, Ge T, Holmes AJ, et al. Morphometricity as a measure of the neuroanatomical signature of a trait. Proc Natl Acad Sci U S A. 2016;113(39):E5749-56. doi:10.1073/pnas.1604378113

Development of Light-Activated CRISPR Using Guide RNAs with Photocleavable Protectors.

Jain PK, Ramanan V, Schepers AG, et al. Development of Light-Activated CRISPR Using Guide RNAs with Photocleavable Protectors. Angew Chem Int Ed Engl. 2016;55(40):12440-4. doi:10.1002/anie.201606123

Schizophyllum commune has an extensive and functional alternative splicing repertoire.

Gehrmann T, Pelkmans JF, Lugones LG, Wösten HAB, Abeel T, Reinders MJT. Schizophyllum commune has an extensive and functional alternative splicing repertoire. Sci Rep. 2016;6:33640. doi:10.1038/srep33640

Structural and Biochemical Basis for Intracellular Kinase Inhibition by Src-specific Peptidic Macrocycles.

Aleem SU, Georghiou G, Kleiner RE, et al. Structural and Biochemical Basis for Intracellular Kinase Inhibition by Src-specific Peptidic Macrocycles. Cell Chem Biol. 2016;23(9):1103-12. doi:10.1016/j.chembiol.2016.07.017

Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia.

Sykes DB, Kfoury YS, Mercier FE, et al. Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia. Cell. 2016;167(1):171-186.e15. doi:10.1016/j.cell.2016.08.057

Adaptive radiation by waves of gene transfer leads to fine-scale resource partitioning in marine microbes.

Hehemann JH, Arevalo P, Datta MS, et al. Adaptive radiation by waves of gene transfer leads to fine-scale resource partitioning in marine microbes. Nat Commun. 2016;7:12860. doi:10.1038/ncomms12860

Prescription medication changes following direct-to-consumer personal genomic testing: findings from the Impact of Personal Genomics (PGen) Study.

Carere DA, VanderWeele TJ, Vassy JL, et al. Prescription medication changes following direct-to-consumer personal genomic testing: findings from the Impact of Personal Genomics (PGen) Study. Genet Med. 2016. doi:10.1038/gim.2016.141

Portable, On-Demand Biomolecular Manufacturing.

Pardee K, Slomovic S, Nguyen PQ, et al. Portable, On-Demand Biomolecular Manufacturing. Cell. 2016;167(1):248-259.e12. doi:10.1016/j.cell.2016.09.013