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Publications

Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1.

Joyal JS, Sun Y, Gantner ML, et al. Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1. Nat Med. 2016;22(4):439-45. doi:10.1038/nm.4059

Rare loss-of-function variants in SETD1A are associated with schizophrenia and developmental disorders.

Singh T, Kurki MI, Curtis D, et al. Rare loss-of-function variants in SETD1A are associated with schizophrenia and developmental disorders. Nat Neurosci. 2016;19(4):571-7. doi:10.1038/nn.4267

The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons.

Braasch I, Gehrke AR, Smith JJ, et al. The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nat Genet. 2016;48(4):427-37. doi:10.1038/ng.3526

Tissue-specific regulatory circuits reveal variable modular perturbations across complex diseases.

Marbach D, Lamparter D, Quon G, Kellis M, Kutalik Z, Bergmann S. Tissue-specific regulatory circuits reveal variable modular perturbations across complex diseases. Nat Methods. 2016;13(4):366-70. doi:10.1038/nmeth.3799

High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines.

Yu C, Mannan AM, Yvone GM, et al. High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines. Nat Biotechnol. 2016;34(4):419-23. doi:10.1038/nbt.3460

Polygenic overlap between schizophrenia risk and antipsychotic response: a genomic medicine approach.

Ruderfer D, Charney A, Readhead B, et al. Polygenic overlap between schizophrenia risk and antipsychotic response: a genomic medicine approach. The lancet. Psychiatry. 2016;3(4):350-7. doi:10.1016/S2215-0366(15)00553-2

Hypoxia as a therapy for mitochondrial disease.

Jain IH, Zazzeron L, Goli R, et al. Hypoxia as a therapy for mitochondrial disease. Science. 2016;352(6281):54-61. doi:10.1126/science.aad9642

Gene co-expression analysis identifies brain regions and cell types involved in migraine pathophysiology: a GWAS-based study using the Allen Human Brain Atlas.

Eising E, Huisman SMH, Mahfouz A, et al. Gene co-expression analysis identifies brain regions and cell types involved in migraine pathophysiology: a GWAS-based study using the Allen Human Brain Atlas. Hum Genet. 2016;135(4):425-39. doi:10.1007/s00439-016-1638-x

Transcriptome-scale RNase-footprinting of RNA-protein complexes.

Ji Z, Song R, Huang H, Regev A, Struhl K. Transcriptome-scale RNase-footprinting of RNA-protein complexes. Nat Biotechnol. 2016;34(4):410-3. doi:10.1038/nbt.3441

Chemoproteomic profiling of host and pathogen enzymes active in cholera.

Hatzios SK, Abel S, Martell J, et al. Chemoproteomic profiling of host and pathogen enzymes active in cholera. Nat Chem Biol. 2016;12(4):268-74. doi:10.1038/nchembio.2025