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Publications

Platelet integrin αIIbβ3 plays a key role in venous thrombogenesis in a mouse model.

Adair BD, Field CO, Alonso JL, et al. Platelet integrin αIIbβ3 plays a key role in venous thrombogenesis in a mouse model. bioRxiv : the preprint server for biology. 2024. doi:10.1101/2024.07.11.602533

Genetic Architecture and Analysis Practices of Circulating Metabolites in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program.

Wang N, Ockerman FP, Zhou LY, et al. Genetic Architecture and Analysis Practices of Circulating Metabolites in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program. bioRxiv : the preprint server for biology. 2024. doi:10.1101/2024.07.23.604849

The glycolytic reaction PGAM unexpectedly restrains Th17 pathogenicity and Th17-dependent autoimmunity.

Wang C, Wagner A, Fessler J, et al. The glycolytic reaction PGAM unexpectedly restrains Th17 pathogenicity and Th17-dependent autoimmunity. bioRxiv : the preprint server for biology. 2024. doi:10.1101/2024.08.18.607992

New opportunities to overcome T cell dysfunction: the role of transcription factors and how to target them.

Wu B, Koehler AN, Westcott PMK. New opportunities to overcome T cell dysfunction: the role of transcription factors and how to target them. Trends in biochemical sciences. 2024. doi:10.1016/j.tibs.2024.08.002

Genome-wide discovery and integrative genomic characterization of insulin resistance loci using serum triglycerides to HDL-cholesterol ratio as a proxy.

DeForest N, Wang Y, Zhu Z, et al. Genome-wide discovery and integrative genomic characterization of insulin resistance loci using serum triglycerides to HDL-cholesterol ratio as a proxy. Nature communications. 2024;15(1):8068. doi:10.1038/s41467-024-52105-y

Sequence variants influencing the regulation of serum IgG subclass levels.

Olafsdottir TA, Thorleifsson G, Portilla AL de L, et al. Sequence variants influencing the regulation of serum IgG subclass levels. Nature communications. 2024;15(1):8054. doi:10.1038/s41467-024-52470-8

Powerful microscopy technologies decode spatially organized cellular networks that drive response to immunotherapy in humans.

Chen JH, Elmelech L, Tang AL, Hacohen N. Powerful microscopy technologies decode spatially organized cellular networks that drive response to immunotherapy in humans. Current opinion in immunology. 2024;91:102463. doi:10.1016/j.coi.2024.102463

Spatial omics advances for in situ RNA biology.

Ren J, Luo S, Shi H, Wang X. Spatial omics advances for in situ RNA biology. Molecular cell. 2024. doi:10.1016/j.molcel.2024.08.002

Semi-supervised machine learning method for predicting homogeneous ancestry groups to assess Hardy-Weinberg equilibrium in diverse whole-genome sequencing studies.

Shyr D, Dey R, Li X, et al. Semi-supervised machine learning method for predicting homogeneous ancestry groups to assess Hardy-Weinberg equilibrium in diverse whole-genome sequencing studies. American journal of human genetics. 2024. doi:10.1016/j.ajhg.2024.08.018

Germline polygenic risk scores are associated with immune gene expression signature and immune cell infiltration in breast cancer.

Liu Y, Peng C, Brorson IS, et al. Germline polygenic risk scores are associated with immune gene expression signature and immune cell infiltration in breast cancer. American journal of human genetics. 2024. doi:10.1016/j.ajhg.2024.08.009