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Publications

Mechanistic insights and biomarker discovery in immune cell aging and age-associated diseases.

Upadhyay P, Suhail A, Khanal P, Kumar S. Mechanistic insights and biomarker discovery in immune cell aging and age-associated diseases. Frontiers in immunology. 2025;16:1637191. doi:10.3389/fimmu.2025.1637191

PMCID

PMC12540116

Author Correction: Towards a reference cell atlas of liver diversity over the human lifespan.

Taylor SA, Bader GD, MacParland S, et al. Author Correction: Towards a reference cell atlas of liver diversity over the human lifespan. Nature reviews. Gastroenterology & hepatology. 2025. doi:10.1038/s41575-025-01145-w

PHLOWER leverages single-cell multimodal data to infer complex, multi-branching cell differentiation trajectories.

Cheng M, Jansen J, Reimer KC, et al. PHLOWER leverages single-cell multimodal data to infer complex, multi-branching cell differentiation trajectories. Nature methods. 2025. doi:10.1038/s41592-025-02870-5

Kmo restricts Salmonella in a whole organism infection model by promoting macrophage lysosomal acidification through kainate receptor antagonism.

Goering ER, Clatworthy AE, Parada-Kusz M, Bagnall J, Hung DT. Kmo restricts Salmonella in a whole organism infection model by promoting macrophage lysosomal acidification through kainate receptor antagonism. PLoS pathogens. 2025;21(10):e1013273. doi:10.1371/journal.ppat.1013273

Active learning framework leveraging transcriptomics identifies modulators of disease phenotypes.

DeMeo B, Nesbitt C, Miller SA, et al. Active learning framework leveraging transcriptomics identifies modulators of disease phenotypes. Science (New York, N.Y.). 2025:eadi8577. doi:10.1126/science.adi8577

Light Exposure at Night and Cardiovascular Disease Incidence.

Windred DP, Burns AC, Rutter MK, et al. Light Exposure at Night and Cardiovascular Disease Incidence. JAMA network open. 2025;8(10):e2539031. doi:10.1001/jamanetworkopen.2025.39031

Acquisition, quality control, and architecture of a large image dataset as a tool for in silico cell biological research.

Konshin N, Valverde MG, Solodennikov D, et al. Acquisition, quality control, and architecture of a large image dataset as a tool for in silico cell biological research. Materials today. Bio. 2025;35:102352. doi:10.1016/j.mtbio.2025.102352

PMCID

PMC12538699

Targeting glutamine catabolism suppresses eosinophil expansion and activation to alleviate allergic airway inflammation.

Du X, Wang Y, Huang J, et al. Targeting glutamine catabolism suppresses eosinophil expansion and activation to alleviate allergic airway inflammation. Biochemical pharmacology. 2025:117443. doi:10.1016/j.bcp.2025.117443

scooby: modeling multimodal genomic profiles from DNA sequence at single-cell resolution.

Hingerl JC, Martens LD, Karollus A, et al. scooby: modeling multimodal genomic profiles from DNA sequence at single-cell resolution. Nature methods. 2025. doi:10.1038/s41592-025-02854-5

Tissue and cellular spatiotemporal dynamics in colon aging.

Daly AC, Cambuli F, Äijö T, et al. Tissue and cellular spatiotemporal dynamics in colon aging. Nature biotechnology. 2025. doi:10.1038/s41587-025-02830-6