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Publications

Replicative stress in gastroesophageal adenocarcinoma is associated with chromosomal instability and sensitivity to DNA damage response inhibitors.

Sahgal P, Patil DT, Sztupinszki ZM, et al. Replicative stress in gastroesophageal adenocarcinoma is associated with chromosomal instability and sensitivity to DNA damage response inhibitors. bioRxiv : the preprint server for biology. 2023. doi:10.1101/2023.03.27.534412

Charting the cellular biogeography in colitis reveals fibroblast trajectories and coordinated spatial remodeling.

Cadinu P, Sivanathan KN, Misra A, et al. Charting the cellular biogeography in colitis reveals fibroblast trajectories and coordinated spatial remodeling. bioRxiv : the preprint server for biology. 2023. doi:10.1101/2023.05.08.539701

Rapid-kinetics degron benchmarking reveals off-target activities and mixed agonism-antagonism of MYB inhibitors.

Harada T, Perez MW, Kalfon J, et al. Rapid-kinetics degron benchmarking reveals off-target activities and mixed agonism-antagonism of MYB inhibitors. bioRxiv : the preprint server for biology. 2023. doi:10.1101/2023.04.07.536032

Identifying metabolic features of colorectal cancer liability using Mendelian randomization.

Bull CJ, Hazelwood E, Bell JA, et al. Identifying metabolic features of colorectal cancer liability using Mendelian randomization. medRxiv : the preprint server for health sciences. 2023. doi:10.1101/2023.03.10.23287084

Towards robust clinical genome interpretation: developing a consistent terminology to characterize disease-gene relationships - allelic requirement, inheritance modes and disease mechanisms.

Roberts AM, DiStefano MT, Riggs ER, et al. Towards robust clinical genome interpretation: developing a consistent terminology to characterize disease-gene relationships - allelic requirement, inheritance modes and disease mechanisms. medRxiv : the preprint server for health sciences. 2023. doi:10.1101/2023.03.30.23287948

Insights from a genome-wide truth set of tandem repeat variation.

Weisburd B, Tiao G, Rehm HL. Insights from a genome-wide truth set of tandem repeat variation. bioRxiv : the preprint server for biology. 2023. doi:10.1101/2023.05.05.539588

The carbapenem inoculum effect provides insight into the molecular mechanisms underlying carbapenem resistance in .

Cartagena AJ, Taylor KL, Smith JT, et al. The carbapenem inoculum effect provides insight into the molecular mechanisms underlying carbapenem resistance in . bioRxiv : the preprint server for biology. 2023. doi:10.1101/2023.05.23.541813

ancIBD - Screening for identity by descent segments in human ancient DNA.

Ringbauer H, Huang Y, Akbari A, Mallick S, Patterson N, Reich D. ancIBD - Screening for identity by descent segments in human ancient DNA. bioRxiv : the preprint server for biology. 2023. doi:10.1101/2023.03.08.531671

Matrix and analysis metadata standards (MAMS) to facilitate harmonization and reproducibility of single-cell data.

Wang Y, Sarfraz I, Teh WK, et al. Matrix and analysis metadata standards (MAMS) to facilitate harmonization and reproducibility of single-cell data. bioRxiv : the preprint server for biology. 2023. doi:10.1101/2023.03.06.531314

Insights into human health from phenome- and genome-wide analyses of UK Biobank retinal optical coherence tomography phenotypes.

Zekavat SM, Jorshery SD, Shweikh Y, et al. Insights into human health from phenome- and genome-wide analyses of UK Biobank retinal optical coherence tomography phenotypes. medRxiv : the preprint server for health sciences. 2023. doi:10.1101/2023.05.16.23290063