ӳ��ý

Publications

Proteome-Wide Association Studies for Blood Lipids and Comparison with Transcriptome-Wide Association Studies.

Zhang D, Gao B, Feng Q, et al. Proteome-Wide Association Studies for Blood Lipids and Comparison with Transcriptome-Wide Association Studies. HGG advances. 2024:100383. doi:10.1016/j.xhgg.2024.100383

A closed-loop modular multiorgan-on-chips platform for self-sustaining and tightly controlled oxygenation.

Jiang N, Ying G, Yin Y, et al. A closed-loop modular multiorgan-on-chips platform for self-sustaining and tightly controlled oxygenation. Proceedings of the National Academy of Sciences of the United States of America. 2024;121(47):e2413684121. doi:10.1073/pnas.2413684121

INF2 mutations cause kidney disease through a gain-of-function mechanism.

Subramanian B, Williams S, Karp S, et al. INF2 mutations cause kidney disease through a gain-of-function mechanism. Science advances. 2024;10(46):eadr1017. doi:10.1126/sciadv.adr1017

Discovery of biophysical rate laws from the electronic health record enables real-time liver injury estimation from transaminase dynamics.

Sherman MS, Goessling W. Discovery of biophysical rate laws from the electronic health record enables real-time liver injury estimation from transaminase dynamics. Cell reports. Medicine. 2024:101828. doi:10.1016/j.xcrm.2024.101828

Catalase activity deficiency sensitizes multidrug-resistant Mycobacterium tuberculosis to the ATP synthase inhibitor bedaquiline.

Ofori-Anyinam B, Hamblin M, Coldren ML, et al. Catalase activity deficiency sensitizes multidrug-resistant Mycobacterium tuberculosis to the ATP synthase inhibitor bedaquiline. Nature communications. 2024;15(1):9792. doi:10.1038/s41467-024-53933-8

Directed evolution of engineered virus-like particles with improved production and transduction efficiencies.

Raguram A, An M, Chen PZ, Liu DR. Directed evolution of engineered virus-like particles with improved production and transduction efficiencies. Nature biotechnology. 2024. doi:10.1038/s41587-024-02467-x

NK2R control of energy expenditure and feeding to treat metabolic diseases.

Sass F, Ma T, Ekberg JH, et al. NK2R control of energy expenditure and feeding to treat metabolic diseases. Nature. 2024. doi:10.1038/s41586-024-08207-0

Targeting heterogeneous tumor microenvironments in pancreatic cancer mouse models of metastasis by TGF-β depletion.

Chen SY, Kung HC, Espinoza B, et al. Targeting heterogeneous tumor microenvironments in pancreatic cancer mouse models of metastasis by TGF-β depletion. JCI insight. 2024;9(21). doi:10.1172/jci.insight.182766

Primary Open-Angle Glaucoma Polygenic Risk Score and Risk of Disease Onset: A Post Hoc Analysis of a Randomized Clinical Trial.

Sekimitsu S, Ghazal N, Aziz K, et al. Primary Open-Angle Glaucoma Polygenic Risk Score and Risk of Disease Onset: A Post Hoc Analysis of a Randomized Clinical Trial. JAMA ophthalmology. 2024. doi:10.1001/jamaophthalmol.2024.4376

Continuous evolution of user-defined genes at 1 million times the genomic mutation rate.

Rix G, Williams RL, Hu VJ, et al. Continuous evolution of user-defined genes at 1 million times the genomic mutation rate. Science (New York, N.Y.). 2024;386(6722):eadm9073. doi:10.1126/science.adm9073