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Publications

Integrative polygenic risk score improves the prediction accuracy of complex traits and diseases.

Truong B, Hull LE, Ruan Y, et al. Integrative polygenic risk score improves the prediction accuracy of complex traits and diseases. medRxiv : the preprint server for health sciences. 2023. doi:10.1101/2023.02.21.23286110

Structurally divergent and recurrently mutated regions of primate genomes.

Mao Y, Harvey WT, Porubsky D, et al. Structurally divergent and recurrently mutated regions of primate genomes. bioRxiv : the preprint server for biology. 2023. doi:10.1101/2023.03.07.531415

Cross-kingdom anti-inflammatory effects of fungal melanin on airway epithelium by post-translational blockade of chemokine secretion.

Reedy JL, Crossen AJ, Ward RA, et al. Cross-kingdom anti-inflammatory effects of fungal melanin on airway epithelium by post-translational blockade of chemokine secretion. bioRxiv : the preprint server for biology. 2023. doi:10.1101/2023.03.28.534632

Contextualizing protein representations using deep learning on protein networks and single-cell data.

Li MM, Huang Y, Sumathipala M, et al. Contextualizing protein representations using deep learning on protein networks and single-cell data. bioRxiv : the preprint server for biology. 2023. doi:10.1101/2023.07.18.549602

Common- and rare-variant genetic architecture of heart failure across the allele frequency spectrum.

Lee DSM, Cardone KM, Zhang DY, et al. Common- and rare-variant genetic architecture of heart failure across the allele frequency spectrum. medRxiv : the preprint server for health sciences. 2023. doi:10.1101/2023.07.16.23292724

Common- and rare-variant genetic architecture of heart failure across the allele frequency spectrum.

Lee DSM, Cardone KM, Zhang DY, et al. Common- and rare-variant genetic architecture of heart failure across the allele frequency spectrum. medRxiv : the preprint server for health sciences. 2023. doi:10.1101/2023.07.16.23292724

Fine-mapping across diverse ancestries drives the discovery of putative causal variants underlying human complex traits and diseases.

Yuan K, Longchamps RJ, Pardiñas AF, et al. Fine-mapping across diverse ancestries drives the discovery of putative causal variants underlying human complex traits and diseases. medRxiv : the preprint server for health sciences. 2023. doi:10.1101/2023.01.07.23284293

Proteogenomic integration reveals CXCL10 as a potentially downstream causal mediator for IL-6 signaling on atherosclerosis.

Prapiadou S, Živković L, Thorand B, et al. Proteogenomic integration reveals CXCL10 as a potentially downstream causal mediator for IL-6 signaling on atherosclerosis. medRxiv : the preprint server for health sciences. 2023. doi:10.1101/2023.03.24.23287543

Cross-ancestry, cell-type-informed atlas of gene, isoform, and splicing regulation in the developing human brain.

Wen C, Margolis M, Dai R, et al. Cross-ancestry, cell-type-informed atlas of gene, isoform, and splicing regulation in the developing human brain. medRxiv : the preprint server for health sciences. 2023. doi:10.1101/2023.03.03.23286706

The genetic architecture of changes in adiposity during adulthood.

Venkatesh SS, Ganjgahi H, Palmer DS, et al. The genetic architecture of changes in adiposity during adulthood. medRxiv : the preprint server for health sciences. 2023. doi:10.1101/2023.01.09.23284364