Publications

Interpreting mammalian synonymous site conservation in light of the unwanted transcript hypothesis.

Christmas MJ, Dong MX, Meadows JRS, Kozyrev S V, Lindblad-Toh K. Interpreting mammalian synonymous site conservation in light of the unwanted transcript hypothesis. Nature communications. 2025;16(1):2007. doi:10.1038/s41467-025-57179-w

Radioprotection of healthy tissue via nanoparticle-delivered mRNA encoding for a damage-suppressor protein found in tardigrades.

Kirtane AR, Bi J, Rajesh NU, et al. Radioprotection of healthy tissue via nanoparticle-delivered mRNA encoding for a damage-suppressor protein found in tardigrades. Nature biomedical engineering. 2025. doi:10.1038/s41551-025-01360-5

Endothelial cell-related genetic variants identify LDL cholesterol-sensitive individuals who derive greater benefit from aggressive lipid lowering.

Marston NA, Kamanu FK, Melloni GEM, et al. Endothelial cell-related genetic variants identify LDL cholesterol-sensitive individuals who derive greater benefit from aggressive lipid lowering. Nature medicine. 2025. doi:10.1038/s41591-025-03533-w

Programs, origins and immunomodulatory functions of myeloid cells in glioma.

Miller TE, Farran CAE, Couturier CP, et al. Programs, origins and immunomodulatory functions of myeloid cells in glioma. Nature. 2025. doi:10.1038/s41586-025-08633-8

Polygenic contributions to lithium augmentation outcomes in antidepressant non-responders with unipolar depression.

Kraft J, Buspavanich P, Braun A, et al. Polygenic contributions to lithium augmentation outcomes in antidepressant non-responders with unipolar depression. medRxiv : the preprint server for health sciences. 2025. doi:10.1101/2025.01.22.25320940

Molecular characterization informs prognosis in patients with localized Ewing sarcoma: A report from the Children's Oncology Group.

Gillani R, Shulman DS, DelRocco NJ, et al. Molecular characterization informs prognosis in patients with localized Ewing sarcoma: A report from the Children’s Oncology Group. medRxiv : the preprint server for health sciences. 2025. doi:10.1101/2025.01.20.25320840

Astrocytic-supplied cholesterol drives synaptic gene expression programs in developing neurons and downstream astrocytic transcriptional programs.

Vartiainen E, Liyanage D, Mazureac I, et al. Astrocytic-supplied cholesterol drives synaptic gene expression programs in developing neurons and downstream astrocytic transcriptional programs. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.01.28.635252

Cholesterol-mediated Lysosomal Dysfunction in Astrocytes Promotes α-Synuclein Pathology in Human Brain Tissue.

Mesentier-Louro LA, Goldman C, Ndayisaba A, et al. Cholesterol-mediated Lysosomal Dysfunction in Astrocytes Promotes α-Synuclein Pathology in Human Brain Tissue. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.02.09.637107

The Neurodegenerative Disease Knowledge Portal: Propelling Discovery Through the Sharing of Neurodegenerative Disease Genomic Resources.

Dilliott AA, Costanzo MC, Bandres-Ciga S, et al. The Neurodegenerative Disease Knowledge Portal: Propelling Discovery Through the Sharing of Neurodegenerative Disease Genomic Resources. Neurology. Genetics. 2025;11(2):e200246. doi:10.1212/NXG.0000000000200246

Simplifying SARS-CoV-2 wastewater-based surveillance using an automated FDA EUA assay.

Sathyanarayana SH, Robins AA, Toledo DM, et al. Simplifying SARS-CoV-2 wastewater-based surveillance using an automated FDA EUA assay. Microbiology spectrum. 2025:e0249024. doi:10.1128/spectrum.02490-24

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Publications

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