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Publications

Retargeted oncolytic viruses engineered to remodel the tumor microenvironment for glioblastoma immunotherapy.

Giovannoni F, Strathdee CA, Akl CF, et al. Retargeted oncolytic viruses engineered to remodel the tumor microenvironment for glioblastoma immunotherapy. Nature cancer. 2025. doi:10.1038/s43018-025-01070-6

The specificity and structure of DNA cross-linking by the gut bacterial genotoxin colibactin.

Carlson ES, Haslecker R, Lecchi C, et al. The specificity and structure of DNA cross-linking by the gut bacterial genotoxin colibactin. Science (New York, N.Y.). 2025;390(6777):eady3571. doi:10.1126/science.ady3571

Lonafarnib Clinical Trials Demonstrate Uncoupling of the Muscle-Bone Unit in Hutchinson-Gilford Progeria Syndrome.

Kreienkamp RJ, Gordon LB, Ehrbar R, et al. Lonafarnib Clinical Trials Demonstrate Uncoupling of the Muscle-Bone Unit in Hutchinson-Gilford Progeria Syndrome. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2025. doi:10.1093/jbmr/zjaf184

Predictive Role of Circulating Tumor DNA in Stage III Colon Cancer Treated With Celecoxib: A Post Hoc Analysis of the CALGB (Alliance)/SWOG 80702 Phase 3 Randomized Clinical Trial.

Zhang GQ, Meyerhardt JA, Shi Q, et al. Predictive Role of Circulating Tumor DNA in Stage III Colon Cancer Treated With Celecoxib: A Post Hoc Analysis of the CALGB (Alliance)/SWOG 80702 Phase 3 Randomized Clinical Trial. JAMA oncology. 2025. doi:10.1001/jamaoncol.2025.5144

Gene editing in "cell villages" enables exploring disease-relevant mutations in many genetic backgrounds.

Battaglia RA, Bolshakova S, Mazureac I, et al. Gene editing in "cell villages" enables exploring disease-relevant mutations in many genetic backgrounds. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.11.08.687374

PMCID

PMC12637643

Preselection CD4CD8 thymocytes modulate TCR responsiveness following TCRβ selection.

Kim EJY, Aylard DA, Steier Z, et al. Preselection CD4CD8 thymocytes modulate TCR responsiveness following TCRβ selection. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.10.03.680384

PMCID

PMC12632616

Coordinated circulating and tissue-based T cell responses precede xenograft rejection.

Novikova E, Severa E, Chen H, et al. Coordinated circulating and tissue-based T cell responses precede xenograft rejection. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.11.07.687259

PMCID

PMC12637509

Ticking Differently: Elucidating Sexual Dimorphism in Human Aging through Metabolomics, Proteomics and Genomics.

Xiao S, Kaushik P, Du G, et al. Ticking Differently: Elucidating Sexual Dimorphism in Human Aging through Metabolomics, Proteomics and Genomics. medRxiv : the preprint server for health sciences. 2025. doi:10.1101/2025.10.30.25339071

PMCID

PMC12636674

MCLRP: enhanced prediction of anticancer drug response through low-rank matrix completion and transcriptomic profiling.

Wang K, Li B, Xu M, et al. MCLRP: enhanced prediction of anticancer drug response through low-rank matrix completion and transcriptomic profiling. BMC biology. 2025. doi:10.1186/s12915-025-02457-8

An efficient solution to Hidden Markov Models on trees with coupled branches.

Vafa F, Hormoz S. An efficient solution to Hidden Markov Models on trees with coupled branches. IEEE transactions on signal processing : a publication of the IEEE Signal Processing Society. 2025;73:4183-4192. doi:10.1109/tsp.2025.3616781

PMCID

PMC12671988