Sullivan PF, Meadows JRS, Gazal S, et al. Leveraging base-pair mammalian constraint to understand genetic variation and human disease. Science (New York, N.Y.). 2023;380(6643):eabn2937. doi:10.1126/science.abn2937
Publications
Christmas MJ, Kaplow IM, Genereux DP, et al. Evolutionary constraint and innovation across hundreds of placental mammals. Science (New York, N.Y.). 2023;380(6643):eabn3943. doi:10.1126/science.abn3943
Xue JR, Mackay-Smith A, Mouri K, et al. The functional and evolutionary impacts of human-specific deletions in conserved elements. Science (New York, N.Y.). 2023;380(6643):eabn2253. doi:10.1126/science.abn2253
Loi S, Settleman J, Joyce JA, et al. The next big questions in cancer research. Cell. 2023;186(8):1523-1527. doi:10.1016/j.cell.2023.01.037
Wieder N, Fried J, Kim C, et al. FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity. Cell metabolism. 2023. doi:10.1016/j.cmet.2023.03.018
Ament SA, Adkins RS, Carter R, et al. The Neuroscience Multi-Omic Archive: a BRAIN Initiative resource for single-cell transcriptomic and epigenomic data from the mammalian brain. Nucleic acids research. 2023;51(D1):D1075-D1085. doi:10.1093/nar/gkac962
Arbab M, Matuszek Z, Kray KM, et al. Base editing rescue of spinal muscular atrophy in cells and in mice. Science (New York, N.Y.). 2023:eadg6518. doi:10.1126/science.adg6518
Lee MS, Dennis C, Naqvi I, et al. Ornithine aminotransferase supports polyamine synthesis in pancreatic cancer. Nature. 2023;616(7956):339-347. doi:10.1038/s41586-023-05891-2
Otto JE, Ursu O, Wu AP, et al. Structural and functional properties of mSWI/SNF chromatin remodeling complexes revealed through single-cell perturbation screens. Molecular cell. 2023. doi:10.1016/j.molcel.2023.03.013
Ren J, Zhou H, Zeng H, et al. Spatiotemporally resolved transcriptomics reveals the subcellular RNA kinetic landscape. Nature methods. 2023. doi:10.1038/s41592-023-01829-8