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Publications

Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment.

Hwang WL, Jagadeesh KA, Guo JA, et al. Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment. Nat Genet. 2022. doi:10.1038/s41588-022-01134-8

Efficient in vivo base editing via single adeno-associated viruses with size-optimized genomes encoding compact adenine base editors.

Davis JR, Wang X, Witte IP, et al. Efficient in vivo base editing via single adeno-associated viruses with size-optimized genomes encoding compact adenine base editors. Nat Biomed Eng. 2022. doi:10.1038/s41551-022-00911-4

Akkermansia muciniphila phospholipid induces homeostatic immune responses.

Bae M, Cassilly CD, Liu X, et al. Akkermansia muciniphila phospholipid induces homeostatic immune responses. Nature. 2022. doi:10.1038/s41586-022-04985-7

Declines in prevalence alter the optimal level of sexual investment for the malaria parasite Plasmodium falciparum.

Early AM, Camponovo F, Pelleau S, et al. Declines in prevalence alter the optimal level of sexual investment for the malaria parasite Plasmodium falciparum. Proc Natl Acad Sci U S A. 2022;119(30):e2122165119. doi:10.1073/pnas.2122165119

Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal HCoVs.

Rebendenne A, Roy P, Bonaventure B, et al. Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal HCoVs. Nat Genet. 2022. doi:10.1038/s41588-022-01110-2

Transcription factor Acj6 controls dendrite targeting via a combinatorial cell-surface code.

Xie Q, Li J, Li H, et al. Transcription factor Acj6 controls dendrite targeting via a combinatorial cell-surface code. Neuron. 2022;110(14):2299-2314.e8. doi:10.1016/j.neuron.2022.04.026

Extrapolating missing antibody-virus measurements across serological studies.

Einav T, Cleary B. Extrapolating missing antibody-virus measurements across serological studies. Cell Syst. 2022. doi:10.1016/j.cels.2022.06.001

Structural variants shape driver combinations and outcomes in pediatric high-grade glioma.

Dubois FPB, Shapira O, Greenwald NF, et al. Structural variants shape driver combinations and outcomes in pediatric high-grade glioma. Nat Cancer. 2022. doi:10.1038/s43018-022-00403-z

Reversal of viral and epigenetic HLA class I repression in Merkel cell carcinoma.

Lee PC, Klaeger S, Le PM, et al. Reversal of viral and epigenetic HLA class I repression in Merkel cell carcinoma. J Clin Invest. 2022;132(13). doi:10.1172/JCI151666

Proteomics and Population Biology in the Cardiovascular Health Study (CHS): design of a study with mentored access and active data sharing.

Austin TR, McHugh CP, Brody JA, et al. Proteomics and Population Biology in the Cardiovascular Health Study (CHS): design of a study with mentored access and active data sharing. Eur J Epidemiol. 2022;37(7):755-765. doi:10.1007/s10654-022-00888-z