Halford JL, Morrill VN, Choi SH, et al. Endophenotype effect sizes support variant pathogenicity in monogenic disease susceptibility genes. Nature communications. 2022;13(1):5106. doi:10.1038/s41467-022-32009-5
Publications
Kartha V, Duarte F, Hu Y, et al. Functional inference of gene regulation using single-cell multi-omics. Cell genomics. 2022;2(9). doi:10.1016/j.xgen.2022.100166
Johnstone S, Gladyshev V, Aryee M, Bernstein B. Epigenetic clocks, aging, and cancer. Science (New York, N.Y.). 2022;378(6626):1276-1277. doi:10.1126/science.abn4009
Miller T, Lareau C, Verga J, et al. Mitochondrial variant enrichment from high-throughput single-cell RNA sequencing resolves clonal populations. Nature biotechnology. 2022;40(7):1030-1034. doi:10.1038/s41587-022-01210-8
Vlaming H, Mimoso C, Field A, Martin B, Adelman K. Screening thousands of transcribed coding and non-coding regions reveals sequence determinants of RNA polymerase II elongation potential. Nature structural & molecular biology. 2022;29(6):613-620. doi:10.1038/s41594-022-00785-9
Boehnke N, Straehla JP, Safford HC, et al. Massively parallel pooled screening reveals genomic determinants of nanoparticle delivery. Science (New York, N.Y.). 2022;377(6604):eabm5551. doi:10.1126/science.abm5551
Gosavi P, Ngan K, Yeo M, et al. Profiling the Landscape of Drug Resistance Mutations in Neosubstrates to Molecular Glue Degraders. ACS central science. 2022;8(4):417-429. doi:10.1021/acscentsci.1c01603
Ngan K. CRISPR-Suppressor Scanning for Systematic Discovery of Drug-Resistance Mutations. Current protocols. 2022;2(12):e614. doi:10.1002/cpz1.614
Wang Q, Li H, Tajima K, et al. Post-translational control of beige fat biogenesis by PRDM16 stabilization. Nature. 2022;609(7925):151-158. doi:10.1038/s41586-022-05067-4
Honecker J, Ruschke S, Seeliger C, et al. Transcriptome and fatty-acid signatures of adipocyte hypertrophy and its non-invasive MR-based characterization in human adipose tissue. EBioMedicine. 2022;79:104020. doi:10.1016/j.ebiom.2022.104020