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Publications

Gut microbial metabolism of 5-ASA diminishes its clinical efficacy in inflammatory bowel disease.

Mehta RS, Mayers JR, Zhang Y, et al. Gut microbial metabolism of 5-ASA diminishes its clinical efficacy in inflammatory bowel disease. Nature medicine. 2023;29(3):700-709. doi:10.1038/s41591-023-02217-7

Hacking hematopoiesis - emerging tools for examining variant effects.

Gundry M, Sankaran VG. Hacking hematopoiesis - emerging tools for examining variant effects. Disease models & mechanisms. 2023;16(3). doi:10.1242/dmm.049857

Granulin loss of function in human mature brain organoids implicates astrocytes in TDP-43 pathology.

de Majo M, Koontz M, Marsan E, et al. Granulin loss of function in human mature brain organoids implicates astrocytes in TDP-43 pathology. Stem cell reports. 2023;18(3):706-719. doi:10.1016/j.stemcr.2023.01.012

Author Correction: FinnGen provides genetic insights from a well-phenotyped isolated population.

Kurki MI, Karjalainen J, Palta P, et al. Author Correction: FinnGen provides genetic insights from a well-phenotyped isolated population. Nature. 2023;615(7952):E19. doi:10.1038/s41586-023-05837-8

Neuropathological features of SARS-CoV-2 delta and omicron variants.

Normandin E, Valizadeh N, Rudmann EA, et al. Neuropathological features of SARS-CoV-2 delta and omicron variants. Journal of neuropathology and experimental neurology. 2023;82(4):283-295. doi:10.1093/jnen/nlad015

Base editing rescue of spinal muscular atrophy in cells and in mice.

Arbab M, Matuszek Z, Kray KM, et al. Base editing rescue of spinal muscular atrophy in cells and in mice. Science (New York, N.Y.). 2023:eadg6518. doi:10.1126/science.adg6518

Engineered allostery in light-regulated LOV-Turbo enables precise spatiotemporal control of proximity labeling in living cells.

Lee SY, Cheah JS, Zhao B, et al. Engineered allostery in light-regulated LOV-Turbo enables precise spatiotemporal control of proximity labeling in living cells. bioRxiv : the preprint server for biology. 2023. doi:10.1101/2023.03.09.531939

Sensitive, high-throughput HLA-I and HLA-II immunopeptidomics using parallel accumulation-serial fragmentation mass spectrometry.

Phulphagar KM, Ctortecka C, Jacome ASV, et al. Sensitive, high-throughput HLA-I and HLA-II immunopeptidomics using parallel accumulation-serial fragmentation mass spectrometry. bioRxiv : the preprint server for biology. 2023. doi:10.1101/2023.03.10.532106

Programmable protein delivery with a bacterial contractile injection system.

Kreitz J, Friedrich M, Guru A, et al. Programmable protein delivery with a bacterial contractile injection system. Nature. 2023. doi:10.1038/s41586-023-05870-7

Base editor scanning charts the DNMT3A activity landscape.

Lue NZ, Garcia EM, Ngan K, Lee C, Doench JG, Liau BB. Base editor scanning charts the DNMT3A activity landscape. Nature chemical biology. 2023;19(2):176-186. doi:10.1038/s41589-022-01167-4