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Publications

Integrating untargeted metabolomics, genetically informed causal inference, and pathway enrichment to define the obesity metabolome.

Hsu YHH, Astley CM, Cole JB, et al. Integrating untargeted metabolomics, genetically informed causal inference, and pathway enrichment to define the obesity metabolome. International journal of obesity (2005). 2020;44(7):1596-1606. doi:10.1038/s41366-020-0603-x

A High Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury during the COVID-19 pandemic.

Alimova M, Sidhom EH, Satyam A, et al. A High Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury during the COVID-19 pandemic. bioRxiv. 2020. doi:10.1101/2020.06.30.180380

Small-Molecule Control of Super-Mendelian Inheritance in Gene Drives.

Del Amo VL, Leger BS, Cox KJ, et al. Small-Molecule Control of Super-Mendelian Inheritance in Gene Drives. Cell Rep. 2020;31(13):107841. doi:10.1016/j.celrep.2020.107841

The PD-1 Pathway Regulates Development and Function of Memory CD8 T Cells following Respiratory Viral Infection.

Pauken KE, Godec J, Odorizzi PM, et al. The PD-1 Pathway Regulates Development and Function of Memory CD8 T Cells following Respiratory Viral Infection. Cell Rep. 2020;31(13):107827. doi:10.1016/j.celrep.2020.107827

Programmable mA modification of cellular RNAs with a Cas13-directed methyltransferase.

Wilson C, Chen PJ, Miao Z, Liu DR. Programmable mA modification of cellular RNAs with a Cas13-directed methyltransferase. Nat Biotechnol. 2020. doi:10.1038/s41587-020-0572-6

Monogenic and polygenic inheritance become instruments for clonal selection.

Loh PR, Genovese G, McCarroll SA. Monogenic and polygenic inheritance become instruments for clonal selection. Nature. 2020. doi:10.1038/s41586-020-2430-6

Genome-wide CRISPR screen reveals host genes that regulate SARS-CoV-2 infection.

Wei J, Alfajaro MM, Hanna RE, et al. Genome-wide CRISPR screen reveals host genes that regulate SARS-CoV-2 infection. bioRxiv. 2020. doi:10.1101/2020.06.16.155101

Cationic zinc is required for factor XII recruitment and activation by stimulated platelets and for thrombus formation in vivo.

Chaudhry SA, Serrata M, Tomczak L, et al. Cationic zinc is required for factor XII recruitment and activation by stimulated platelets and for thrombus formation in vivo. J Thromb Haemost. 2020. doi:10.1111/jth.14964

Cholesterol Metabolism by Uncultured Human Gut Bacteria Influences Host Cholesterol Level.

Kenny DJ, Plichta DR, Shungin D, et al. Cholesterol Metabolism by Uncultured Human Gut Bacteria Influences Host Cholesterol Level. Cell Host Microbe. 2020. doi:10.1016/j.chom.2020.05.013

Determinants of Base Editing Outcomes from Target Library Analysis and Machine Learning.

Arbab M, Shen MW, Mok B, et al. Determinants of Base Editing Outcomes from Target Library Analysis and Machine Learning. Cell. 2020. doi:10.1016/j.cell.2020.05.037