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Publications

Inducible histone K-to-M mutations are dynamic tools to probe the physiological role of site-specific histone methylation in vitro and in vivo.

Brumbaugh J, Kim IS, Ji F, et al. Inducible histone K-to-M mutations are dynamic tools to probe the physiological role of site-specific histone methylation in vitro and in vivo. Nat Cell Biol. 2019. doi:10.1038/s41556-019-0403-5

Structural basis for the docking of mTORC1 on the lysosomal surface.

Rogala KB, Gu X, Kedir JF, et al. Structural basis for the docking of mTORC1 on the lysosomal surface. Science. 2019;366(6464):468-475. doi:10.1126/science.aay0166

Single-cell transcriptomic atlas of the human retina identifies cell types associated with age-related macular degeneration.

Menon M, Mohammadi S, Davila-Velderrain J, et al. Single-cell transcriptomic atlas of the human retina identifies cell types associated with age-related macular degeneration. Nat Commun. 2019;10(1):4902. doi:10.1038/s41467-019-12780-8

A rapid triage test for active pulmonary tuberculosis in adult patients with persistent cough.

Ahmad R, Xie L, Pyle M, et al. A rapid triage test for active pulmonary tuberculosis in adult patients with persistent cough. Sci Transl Med. 2019;11(515). doi:10.1126/scitranslmed.aaw8287

Search-and-replace genome editing without double-strand breaks or donor DNA.

Anzalone AV, Randolph PB, Davis JR, et al. Search-and-replace genome editing without double-strand breaks or donor DNA. Nature. 2019. doi:10.1038/s41586-019-1711-4

Absolute Free Energy of Binding Calculations for Macrophage Migration Inhibitory Factor in Complex with a Druglike Inhibitor.

Qian Y, de Vaca IC, Vilseck JZ, Cole DJ, Tirado-Rives J, Jorgensen WL. Absolute Free Energy of Binding Calculations for Macrophage Migration Inhibitory Factor in Complex with a Druglike Inhibitor. J Phys Chem B. 2019;123(41):8675-8685. doi:10.1021/acs.jpcb.9b07588

Genome-wide Association Studies in Ancestrally Diverse Populations: Opportunities, Methods, Pitfalls, and Recommendations.

Peterson RE, Kuchenbaecker K, Walters RK, et al. Genome-wide Association Studies in Ancestrally Diverse Populations: Opportunities, Methods, Pitfalls, and Recommendations. Cell. 2019;179(3):589-603. doi:10.1016/j.cell.2019.08.051

Optical Pooled Screens in Human Cells.

Feldman D, Singh A, Schmid-Burgk JL, et al. Optical Pooled Screens in Human Cells. Cell. 2019;179(3):787-799.e17. doi:10.1016/j.cell.2019.09.016

Altered chromosomal topology drives oncogenic programs in SDH-deficient GIST.

Flavahan WA, Drier Y, Johnstone SE, et al. Altered chromosomal topology drives oncogenic programs in SDH-deficient GIST. Nature. 2019. doi:10.1038/s41586-019-1668-3

Gain-of-Function Claims for Type-2-Diabetes-Associated Coding Variants in SLC16A11 Are Not Supported by the Experimental Data.

Hoch E, Florez JC, Lander ES, Jacobs SBR. Gain-of-Function Claims for Type-2-Diabetes-Associated Coding Variants in SLC16A11 Are Not Supported by the Experimental Data. Cell Rep. 2019;29(3):778-780. doi:10.1016/j.celrep.2019.09.021