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Publications

Mutations in RABL3 alter KRAS prenylation and are associated with hereditary pancreatic cancer.

Nissim S, Leshchiner I, Mancias JD, et al. Mutations in RABL3 alter KRAS prenylation and are associated with hereditary pancreatic cancer. Nat Genet. 2019;51(9):1308-1314. doi:10.1038/s41588-019-0475-y

A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.

Poyet M, Groussin M, Gibbons SM, et al. A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research. Nat Med. 2019;25(9):1442-1452. doi:10.1038/s41591-019-0559-3

Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers.

Parikh AR, Leshchiner I, Elagina L, et al. Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers. Nat Med. 2019;25(9):1415-1421. doi:10.1038/s41591-019-0561-9

Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior.

Ganna A, Verweij KJH, Nivard MG, et al. Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior. Science. 2019;365(6456). doi:10.1126/science.aat7693

Influence of agricultural antibiotic use on chicken meat-associated enterococci and their connection to the clinic.

Manson AL, Van Tyne D, Straub TJ, et al. Influence of agricultural antibiotic use on chicken meat-associated enterococci and their connection to the clinic. Appl Environ Microbiol. 2019. doi:10.1128/AEM.01559-19

CHIPing away at breast cancer.

Sperling AS, Ebert BL. CHIPing away at breast cancer. J Natl Cancer Inst. 2019. doi:10.1093/jnci/djz158

Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors.

Oberlick EM, Rees MG, Seashore-Ludlow B, et al. Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors. Cell Rep. 2019;28(9):2331-2344.e8. doi:10.1016/j.celrep.2019.07.021

Bacterial metabolic state more accurately predicts antibiotic lethality than growth rate.

Lopatkin AJ, Stokes JM, Zheng EJ, et al. Bacterial metabolic state more accurately predicts antibiotic lethality than growth rate. Nat Microbiol. 2019. doi:10.1038/s41564-019-0536-0

Programmable CRISPR-responsive smart materials.

English MA, Soenksen LR, Gayet RV, et al. Programmable CRISPR-responsive smart materials. Science. 2019;365(6455):780-785. doi:10.1126/science.aaw5122

Therapeutic Opportunities in Inflammatory Bowel Disease: Mechanistic Dissection of Host-Microbiome Relationships.

Plichta DR, Graham DB, Subramanian S, Xavier RJ. Therapeutic Opportunities in Inflammatory Bowel Disease: Mechanistic Dissection of Host-Microbiome Relationships. Cell. 2019;178(5):1041-1056. doi:10.1016/j.cell.2019.07.045