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Proteomics Platform

Ribosomal mutations promote the evolution of antibiotic resistance in a multidrug environment.

Gomez JE, Kaufmann-Malaga BB, Wivagg CN, et al. Ribosomal mutations promote the evolution of antibiotic resistance in a multidrug environment. Elife. 2017;6. doi:10.7554/eLife.20420

Castration Resistance in Prostate Cancer Is Mediated by the Kinase NEK6.

Choudhury AD, Schinzel AC, Cotter MB, et al. Castration Resistance in Prostate Cancer Is Mediated by the Kinase NEK6. Cancer Res. 2017;77(3):753-765. doi:10.1158/0008-5472.CAN-16-0455

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.

Naba A, Clauser KR, Mani DR, Carr SA, Hynes RO. Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Sci Rep. 2017;7:40495. doi:10.1038/srep40495

Proteome Profiling Outperforms Transcriptome Profiling for Coexpression Based Gene Function Prediction.

Wang J, Ma Z, Carr SA, et al. Proteome Profiling Outperforms Transcriptome Profiling for Coexpression Based Gene Function Prediction. Mol Cell Proteomics. 2017;16(1):121-134. doi:10.1074/mcp.M116.060301

TMEM258 Is a Component of the Oligosaccharyltransferase Complex Controlling ER Stress and Intestinal Inflammation.

Graham DB, Lefkovith A, Deelen P, et al. TMEM258 Is a Component of the Oligosaccharyltransferase Complex Controlling ER Stress and Intestinal Inflammation. Cell Rep. 2016;17(11):2955-2965. doi:10.1016/j.celrep.2016.11.042

Transcriptional categorization of the etiology of pneumonia syndrome in pediatric patients in malaria endemic areas.

Silterra J, Gillette MA, Lanaspa M, et al. Transcriptional categorization of the etiology of pneumonia syndrome in pediatric patients in malaria endemic areas. J Infect Dis. 2016. doi:10.1093/infdis/jiw531

Reconstituted B cell receptor signaling reveals carbohydrate-dependent mode of activation.

Villar RF, Patel J, Weaver GC, et al. Reconstituted B cell receptor signaling reveals carbohydrate-dependent mode of activation. Sci Rep. 2016;6:36298. doi:10.1038/srep36298

A proposal for validation of antibodies.

Uhlen M, Bandrowski A, Carr S, et al. A proposal for validation of antibodies. Nat Methods. 2016;13(10):823-7. doi:10.1038/nmeth.3995

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.

Rosenbluh J, Mercer J, Shrestha Y, et al. Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers. Cell Syst. 2016;3(3):302-316.e4. doi:10.1016/j.cels.2016.09.001

Proteomic Analysis of Unbounded Cellular Compartments: Synaptic Clefts.

Loh KH, Stawski PS, Draycott AS, et al. Proteomic Analysis of Unbounded Cellular Compartments: Synaptic Clefts. Cell. 2016;166(5):1295-1307.e21. doi:10.1016/j.cell.2016.07.041