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Proteomics Platform

Nitric Oxide Engages an Anti-inflammatory Feedback Loop Mediated by Peroxiredoxin 5 in Phagocytes.

Graham DB, Jasso GJ, Mok A, et al. Nitric Oxide Engages an Anti-inflammatory Feedback Loop Mediated by Peroxiredoxin 5 in Phagocytes. Cell Rep. 2018;24(4):838-850. doi:10.1016/j.celrep.2018.06.081

Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition.

Wong GS, Zhou J, Bin Liu J, et al. Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition. Nat Med. 2018;24(7):968-977. doi:10.1038/s41591-018-0022-x

The C9orf72-interacting protein Smcr8 is a negative regulator of autoimmunity and lysosomal exocytosis.

Zhang Y, Burberry A, Wang JY, et al. The C9orf72-interacting protein Smcr8 is a negative regulator of autoimmunity and lysosomal exocytosis. Genes Dev. 2018;32(13-14):929-943. doi:10.1101/gad.313932.118

Anti-apoptotic Protein BIRC5 Maintains Survival of HIV-1-Infected CD4 T Cells.

Kuo HH, Ahmad R, Lee GQ, et al. Anti-apoptotic Protein BIRC5 Maintains Survival of HIV-1-Infected CD4 T Cells. Immunity. 2018;48(6):1183-1194.e5. doi:10.1016/j.immuni.2018.04.004

Harnessing single-cell genomics to improve the physiological fidelity of organoid-derived cell types.

Mead BE, Ordovas-Montanes J, Braun AP, et al. Harnessing single-cell genomics to improve the physiological fidelity of organoid-derived cell types. BMC Biol. 2018;16(1):62. doi:10.1186/s12915-018-0527-2

Discovery of proteins associated with a predefined genomic locus via dCas9-APEX-mediated proximity labeling.

Myers SA, Wright J, Peckner R, Kalish BT, Zhang F, Carr SA. Discovery of proteins associated with a predefined genomic locus via dCas9-APEX-mediated proximity labeling. Nat Methods. 2018;15(6):437-439. doi:10.1038/s41592-018-0007-1

Panorama Public: A Public Repository for Quantitative Data Sets Processed in Skyline.

Sharma V, Eckels J, Schilling B, et al. Panorama Public: A Public Repository for Quantitative Data Sets Processed in Skyline. Mol Cell Proteomics. 2018;17(6):1239-1244. doi:10.1074/mcp.RA117.000543

Specter: linear deconvolution for targeted analysis of data-independent acquisition mass spectrometry proteomics.

Peckner R, Myers SA, Jacome AS, et al. Specter: linear deconvolution for targeted analysis of data-independent acquisition mass spectrometry proteomics. Nat Methods. 2018;15(5):371-378. doi:10.1038/nmeth.4643

A Library of Phosphoproteomic and Chromatin Signatures for Characterizing Cellular Responses to Drug Perturbations.

Litichevskiy L, Peckner R, Abelin JG, et al. A Library of Phosphoproteomic and Chromatin Signatures for Characterizing Cellular Responses to Drug Perturbations. Cell Syst. 2018;6(4):424-443.e7. doi:10.1016/j.cels.2018.03.012

Ribosome Levels Selectively Regulate Translation and Lineage Commitment in Human Hematopoiesis.

Khajuria RK, Munschauer M, Ulirsch JC, et al. Ribosome Levels Selectively Regulate Translation and Lineage Commitment in Human Hematopoiesis. Cell. 2018;173(1):90-103.e19. doi:10.1016/j.cell.2018.02.036