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Publications

De novo assembly of the Aedes aegypti genome using Hi-C yields chromosome-length scaffolds.

Dudchenko O, Batra SS, Omer AD, et al. De novo assembly of the Aedes aegypti genome using Hi-C yields chromosome-length scaffolds. Science. 2017;356(6333):92-95. doi:10.1126/science.aal3327

The Value of FLG Null Mutations in Predicting Treatment Response in Atopic Dermatitis: An Observational Study in Finnish Patients.

Luukkonen TM, Kiiski V, Ahola M, et al. The Value of FLG Null Mutations in Predicting Treatment Response in Atopic Dermatitis: An Observational Study in Finnish Patients. Acta Derm Venereol. 2017;97(4):456-463. doi:10.2340/00015555-2578

Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase.

Cantor JR, Abu-Remaileh M, Kanarek N, et al. Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase. Cell. 2017;169(2):258-272.e17. doi:10.1016/j.cell.2017.03.023

The NextGen Genetic Association Studies Consortium: A Foray into In Vitro Population Genetics.

Warren CR, Jaquish CE, Cowan CA. The NextGen Genetic Association Studies Consortium: A Foray into In Vitro Population Genetics. Cell Stem Cell. 2017;20(4):431-433. doi:10.1016/j.stem.2017.03.021

Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease.

Warren CR, O’Sullivan JF, Friesen M, et al. Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease. Cell Stem Cell. 2017;20(4):547-557.e7. doi:10.1016/j.stem.2017.01.010

Large, Diverse Population Cohorts of hiPSCs and Derived Hepatocyte-like Cells Reveal Functional Genetic Variation at Blood Lipid-Associated Loci.

Pashos EE, Park Y, Wang X, et al. Large, Diverse Population Cohorts of hiPSCs and Derived Hepatocyte-like Cells Reveal Functional Genetic Variation at Blood Lipid-Associated Loci. Cell Stem Cell. 2017;20(4):558-570.e10. doi:10.1016/j.stem.2017.03.017

Human Demographic History Impacts Genetic Risk Prediction across Diverse Populations.

Martin AR, Gignoux CR, Walters RK, et al. Human Demographic History Impacts Genetic Risk Prediction across Diverse Populations. Am J Hum Genet. 2017;100(4):635-649. doi:10.1016/j.ajhg.2017.03.004

Myeloid progenitor cluster formation drives emergency and leukaemic myelopoiesis.

Herault A, Binnewies M, Leong S, et al. Myeloid progenitor cluster formation drives emergency and leukaemic myelopoiesis. Nature. 2017;544(7648):53-58. doi:10.1038/nature21693

Functional Architectures of Local and Distal Regulation of Gene Expression in Multiple Human Tissues.

Liu X, Finucane HK, Gusev A, et al. Functional Architectures of Local and Distal Regulation of Gene Expression in Multiple Human Tissues. Am J Hum Genet. 2017;100(4):605-616. doi:10.1016/j.ajhg.2017.03.002

Large-Scale trans-eQTLs Affect Hundreds of Transcripts and Mediate Patterns of Transcriptional Co-regulation.

Brynedal B, Choi J, Raj T, et al. Large-Scale trans-eQTLs Affect Hundreds of Transcripts and Mediate Patterns of Transcriptional Co-regulation. Am J Hum Genet. 2017;100(4):581-591. doi:10.1016/j.ajhg.2017.02.004