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Publications

Microbial strain-level population structure and genetic diversity from metagenomes.

Truong DT, Tett A, Pasolli E, Huttenhower C, Segata N. Microbial strain-level population structure and genetic diversity from metagenomes. Genome Res. 2017;27(4):626-638. doi:10.1101/gr.216242.116

Deletion of ribosomal protein genes is a common vulnerability in human cancer, especially in concert with TP53 mutations.

Ajore R, Raiser D, McConkey M, et al. Deletion of ribosomal protein genes is a common vulnerability in human cancer, especially in concert with TP53 mutations. EMBO Mol Med. 2017;9(4):498-507. doi:10.15252/emmm.201606660

Limited statistical evidence for shared genetic effects of eQTLs and autoimmune-disease-associated loci in three major immune-cell types.

Chun S, Casparino A, Patsopoulos NA, et al. Limited statistical evidence for shared genetic effects of eQTLs and autoimmune-disease-associated loci in three major immune-cell types. Nat Genet. 2017;49(4):600-605. doi:10.1038/ng.3795

Subcortical brain volume differences in participants with attention deficit hyperactivity disorder in children and adults: a cross-sectional mega-analysis.

Hoogman M, Bralten J, Hibar DP, et al. Subcortical brain volume differences in participants with attention deficit hyperactivity disorder in children and adults: a cross-sectional mega-analysis. Lancet Psychiatry. 2017;4(4):310-319. doi:10.1016/S2215-0366(17)30049-4

The Weighting is the Hardest Part: On the Behavior of the Likelihood Ratio Test and the Score Test Under a Data-Driven Weighting Scheme in Sequenced Samples.

Minică CC, Genovese G, Hultman CM, et al. The Weighting is the Hardest Part: On the Behavior of the Likelihood Ratio Test and the Score Test Under a Data-Driven Weighting Scheme in Sequenced Samples. Twin Res Hum Genet. 2017;20(2):108-118. doi:10.1017/thg.2017.7

TOP2 synergizes with BAF chromatin remodeling for both resolution and formation of facultative heterochromatin.

Miller EL, Hargreaves DC, Kadoch C, et al. TOP2 synergizes with BAF chromatin remodeling for both resolution and formation of facultative heterochromatin. Nat Struct Mol Biol. 2017;24(4):344-352. doi:10.1038/nsmb.3384

Biallelic mutations in human DCC cause developmental split-brain syndrome.

Jamuar SS, Schmitz-Abe K, D’Gama AM, et al. Biallelic mutations in human DCC cause developmental split-brain syndrome. Nat Genet. 2017;49(4):606-612. doi:10.1038/ng.3804

Olig1 is required for noggin-induced neonatal myelin repair.

Sabo JK, Heine V, Silbereis JC, Schirmer L, Levison SW, Rowitch DH. Olig1 is required for noggin-induced neonatal myelin repair. Ann Neurol. 2017;81(4):560-571. doi:10.1002/ana.24907

Refining the role of de novo protein-truncating variants in neurodevelopmental disorders by using population reference samples.

Kosmicki JA, Samocha KE, Howrigan DP, et al. Refining the role of de novo protein-truncating variants in neurodevelopmental disorders by using population reference samples. Nat Genet. 2017;49(4):504-510. doi:10.1038/ng.3789

Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions.

Kim B, Komor AC, Levy JM, Packer MS, Zhao KT, Liu DR. Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions. Nat Biotechnol. 2017;35(4):371-376. doi:10.1038/nbt.3803