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Publications

A Polygenic Risk Score to Predict Incident Heart Failure Across the Spectrum of Cardiovascular Risk.

Haller PM, Melloni GEM, Berg DD, et al. A Polygenic Risk Score to Predict Incident Heart Failure Across the Spectrum of Cardiovascular Risk. Journal of the American College of Cardiology. 2025;86(12):860-873. doi:10.1016/j.jacc.2025.06.050

Cross-biobank generalizability and accuracy of electronic health record-based predictors compared to polygenic scores.

Detrois KE, Hartonen T, Teder-Laving M, et al. Cross-biobank generalizability and accuracy of electronic health record-based predictors compared to polygenic scores. Nature genetics. 2025;57(9):2136-2145. doi:10.1038/s41588-025-02298-9

Tamoxifen induces PI3K activation in uterine cancer.

Kübler K, Nardone A, Anand S, et al. Tamoxifen induces PI3K activation in uterine cancer. Nature genetics. 2025;57(9):2192-2202. doi:10.1038/s41588-025-02308-w

Heart Failure Prediction in Dysglycemia: Are We Ready to Trust the Proteome?

Ahmadizar F, Paruchuri K. Heart Failure Prediction in Dysglycemia: Are We Ready to Trust the Proteome? European journal of preventive cardiology. 2025. doi:10.1093/eurjpc/zwaf570

p300/CBP is an essential driver of pathogenic enhancer activity and gene expression in Ewing sarcoma.

Godfrey LC, Regalado B, Schweber SR, et al. p300/CBP is an essential driver of pathogenic enhancer activity and gene expression in Ewing sarcoma. EMBO reports. 2025. doi:10.1038/s44319-025-00552-z

Mitigating antimicrobial resistance by innovative solutions in AI (MARISA): a modified James Lind Alliance analysis.

Waldock WJ, Thould H, Chindelevitch L, et al. Mitigating antimicrobial resistance by innovative solutions in AI (MARISA): a modified James Lind Alliance analysis. npj antimicrobials and resistance. 2025;3(1):75. doi:10.1038/s44259-025-00150-y

Translon: a single term for translated regions.

Świrski MI, Tierney JAS, Albà M, et al. Translon: a single term for translated regions. Nature methods. 2025. doi:10.1038/s41592-025-02810-3

Defining the antitumor mechanism of action of a clinical-stage compound as a selective degrader of the nuclear pore complex.

Yuan L, Ji W, Dwyer BG, et al. Defining the antitumor mechanism of action of a clinical-stage compound as a selective degrader of the nuclear pore complex. Cancer discovery. 2025. doi:10.1158/2159-8290.CD-25-0271

Leveraging Large Language Models in Extracting Drug Safety Information from Prescription Drug Labels.

Gisladottir U, Zietz M, Kivelson S, et al. Leveraging Large Language Models in Extracting Drug Safety Information from Prescription Drug Labels. Drug safety. 2025. doi:10.1007/s40264-025-01594-x

The RNA-binding protein TRIM71 is essential for hearing in humans and mice and times auditory sensory organ development.

Li XJ, Morgan C, Duy PQ, et al. The RNA-binding protein TRIM71 is essential for hearing in humans and mice and times auditory sensory organ development. Proceedings of the National Academy of Sciences of the United States of America. 2025;122(36):e2505811122. doi:10.1073/pnas.2505811122