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Publications

Mechanism of Action of KL-50, a Candidate Imidazotetrazine for the Treatment of Drug-Resistant Brain Cancers.

Huseman ED, Lo A, Fedorova O, et al. Mechanism of Action of KL-50, a Candidate Imidazotetrazine for the Treatment of Drug-Resistant Brain Cancers. Journal of the American Chemical Society. 2024. doi:10.1021/jacs.3c06483

Statin prevents cancer development in chronic inflammation by blocking interleukin 33 expression.

Park JH, Mortaja M, Son HG, et al. Statin prevents cancer development in chronic inflammation by blocking interleukin 33 expression. Nature communications. 2024;15(1):4099. doi:10.1038/s41467-024-48441-8

Inflammation causes insulin resistance in mice via interferon regulatory factor 3 (IRF3)-mediated reduction in FAHFA levels.

Yan S, Santoro A, Niphakis MJ, et al. Inflammation causes insulin resistance in mice via interferon regulatory factor 3 (IRF3)-mediated reduction in FAHFA levels. Nature communications. 2024;15(1):4605. doi:10.1038/s41467-024-48220-5

Biallelic variants in CSMD1 are implicated in a neurodevelopmental disorder with intellectual disability and variable cortical malformations.

Werren EA, Peirent ER, Jäntti H, et al. Biallelic variants in CSMD1 are implicated in a neurodevelopmental disorder with intellectual disability and variable cortical malformations. Cell death & disease. 2024;15(5):379. doi:10.1038/s41419-024-06768-6

Effects and safety of transcranial direct current stimulation on multiple health outcomes: an umbrella review of randomized clinical trials.

Kang J, Lee H, Yu S, et al. Effects and safety of transcranial direct current stimulation on multiple health outcomes: an umbrella review of randomized clinical trials. Molecular psychiatry. 2024. doi:10.1038/s41380-024-02624-3

SCENT defines non-coding disease mechanisms using single-cell multi-omics.

Sakaue S. SCENT defines non-coding disease mechanisms using single-cell multi-omics. Nature reviews. Genetics. 2024. doi:10.1038/s41576-024-00747-5

Laboratory testing for preconception/prenatal carrier screening: A technical standard of the American College of Medical Genetics and Genomics (ACMG).

Guha S, Reddi H V, Aarabi M, et al. Laboratory testing for preconception/prenatal carrier screening: A technical standard of the American College of Medical Genetics and Genomics (ACMG). Genetics in medicine : official journal of the American College of Medical Genetics. 2024:101137. doi:10.1016/j.gim.2024.101137

CMTR-1 RNA methyltransferase mutations activate widespread expression of a dopaminergic neuron-specific mitochondrial complex I gene.

Meisel JD, Wiesenthal PP, Mootha VK, Ruvkun G. CMTR-1 RNA methyltransferase mutations activate widespread expression of a dopaminergic neuron-specific mitochondrial complex I gene. Current biology : CB. 2024. doi:10.1016/j.cub.2024.04.079

On knowing a gene: A distributional hypothesis of gene function.

Kwon JJ, Pan J, Gonzalez G, Hahn WC, Zitnik M. On knowing a gene: A distributional hypothesis of gene function. Cell systems. 2024. doi:10.1016/j.cels.2024.04.008

Genetic predisposition to high BMI increases risk of early life respiratory infections and episodes of severe wheeze and asthma.

Jensen SK, Pedersen CET, Fischer-Rasmussen K, et al. Genetic predisposition to high BMI increases risk of early life respiratory infections and episodes of severe wheeze and asthma. The European respiratory journal. 2024. doi:10.1183/13993003.00169-2024