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Publications

Blocking the angiopoietin-2-dependent integrin β-1 signaling axis abrogates small cell lung cancer invasion and metastasis.

Meder L, Orschel CI, Otto CJ, et al. Blocking the angiopoietin-2-dependent integrin β-1 signaling axis abrogates small cell lung cancer invasion and metastasis. JCI insight. 2024;9(10). doi:10.1172/jci.insight.166402

Fetal brain response to maternal inflammation requires microglia.

Ostrem BEL, Domínguez-Iturza N, Stogsdill JA, et al. Fetal brain response to maternal inflammation requires microglia. Development (Cambridge, England). 2024;151(10). doi:10.1242/dev.202252

SAFPred: Synteny-aware gene function prediction for bacteria using protein embeddings.

Urhan A, Cosma BM, Earl AM, Manson AL, Abeel T. SAFPred: Synteny-aware gene function prediction for bacteria using protein embeddings. Bioinformatics (Oxford, England). 2024. doi:10.1093/bioinformatics/btae328

Dystonia and mitochondrial disease: the movement disorder connection revisited in 900 genetically diagnosed patients.

Indelicato E, Schlieben LD, Stenton SL, et al. Dystonia and mitochondrial disease: the movement disorder connection revisited in 900 genetically diagnosed patients. Journal of neurology. 2024. doi:10.1007/s00415-024-12447-5

Key Roles of CACNA1C/Cav1.2 and CALB1/Calbindin in Prefrontal Neurons Altered in Cognitive Disorders.

Datta D, Yang S, Joyce MKP, et al. Key Roles of CACNA1C/Cav1.2 and CALB1/Calbindin in Prefrontal Neurons Altered in Cognitive Disorders. JAMA psychiatry. 2024. doi:10.1001/jamapsychiatry.2024.1112

The CTLH Ubiquitin Ligase Substrates ZMYND19 and MKLN1 Negatively Regulate mTORC1 at the Lysosomal Membrane.

Wang Y, Guo R, Piedras BI, et al. The CTLH Ubiquitin Ligase Substrates ZMYND19 and MKLN1 Negatively Regulate mTORC1 at the Lysosomal Membrane. Research square. 2024. doi:10.21203/rs.3.rs-4259395/v1

Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming.

Holman CD, Sakers AP, Calhoun RP, et al. Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming. eLife. 2024;12. doi:10.7554/eLife.87756

Discovery and validation of plasma, saliva and multi-fluid plasma-saliva metabolomic scores predicting insulin resistance and diabetes progression or regression among Puerto Rican adults.

Haslam DE, Liang L, Guo K, et al. Discovery and validation of plasma, saliva and multi-fluid plasma-saliva metabolomic scores predicting insulin resistance and diabetes progression or regression among Puerto Rican adults. Diabetologia. 2024. doi:10.1007/s00125-024-06169-6

Deep learning of left atrial structure and function provides link to atrial fibrillation risk.

Pirruccello JP, Di Achille P, Choi SH, et al. Deep learning of left atrial structure and function provides link to atrial fibrillation risk. Nature communications. 2024;15(1):4304. doi:10.1038/s41467-024-48229-w

Cell of origin epigenetic priming determines susceptibility to Tet2 mutation.

Schiroli G, Kartha V, Duarte FM, et al. Cell of origin epigenetic priming determines susceptibility to Tet2 mutation. Nature communications. 2024;15(1):4325. doi:10.1038/s41467-024-48508-6