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Publications

Discovery and Characterization of Selective, First-in-Class Inhibitors of Citron Kinase.

Maw JJ, Coker JA, Arya T, et al. Discovery and Characterization of Selective, First-in-Class Inhibitors of Citron Kinase. Journal of medicinal chemistry. 2024. doi:10.1021/acs.jmedchem.3c01807

Glycan-costumed virus-like particles promote type 1 anti-tumor immunity.

Lensch V, Gabba A, Hincapie R, et al. Glycan-costumed virus-like particles promote type 1 anti-tumor immunity. bioRxiv : the preprint server for biology. 2024. doi:10.1101/2024.01.18.575711

Mitochondrial dysfunction in Spaceflight Associated Neuro-Ocular Syndrome (SANS): a molecular hypothesis in pathogenesis.

Waisberg E, Ong J, Masalkhi M, Mao XW, Beheshti A, Lee AG. Mitochondrial dysfunction in Spaceflight Associated Neuro-Ocular Syndrome (SANS): a molecular hypothesis in pathogenesis. Eye (London, England). 2024. doi:10.1038/s41433-024-02951-3

Genome-wide association study identifies human genetic variants associated with fatal outcome from Lassa fever.

Kotliar D, Raju S, Tabrizi S, et al. Genome-wide association study identifies human genetic variants associated with fatal outcome from Lassa fever. Nature microbiology. 2024. doi:10.1038/s41564-023-01589-3

Convergence of coronary artery disease genes onto endothelial cell programs.

Schnitzler GR, Kang H, Fang S, et al. Convergence of coronary artery disease genes onto endothelial cell programs. Nature. 2024. doi:10.1038/s41586-024-07022-x

De-obstruction of bladder outlet in humans reverses organ remodelling by normalizing the expression of key transcription factors.

Akshay A, Gheinani AH, Besic M, et al. De-obstruction of bladder outlet in humans reverses organ remodelling by normalizing the expression of key transcription factors. BMC urology. 2024;24(1):33. doi:10.1186/s12894-024-01417-8

Understanding Mechanisms of Response to CAR T-cell Therapy through Single-Cell Sequencing: Insights and Challenges.

Haradhvala NJ, Maus M V. Understanding Mechanisms of Response to CAR T-cell Therapy through Single-Cell Sequencing: Insights and Challenges. Blood cancer discovery. 2024:OF1-OF4. doi:10.1158/2643-3230.BCD-23-0212

A clinically applicable connectivity signature for glioblastoma includes the tumor network driver CHI3L1.

Hai L, Hoffmann DC, Wagener RJ, et al. A clinically applicable connectivity signature for glioblastoma includes the tumor network driver CHI3L1. Nature communications. 2024;15(1):968. doi:10.1038/s41467-024-45067-8

Efficient prime editing in two-cell mouse embryos using PEmbryo.

Kim-Yip RP, McNulty R, Joyce B, et al. Efficient prime editing in two-cell mouse embryos using PEmbryo. Nature biotechnology. 2024. doi:10.1038/s41587-023-02106-x

Transcriptome-wide association study of the plasma proteome reveals cis and trans regulatory mechanisms underlying complex traits.

Wittich H, Ardlie K, Taylor KD, et al. Transcriptome-wide association study of the plasma proteome reveals cis and trans regulatory mechanisms underlying complex traits. American journal of human genetics. 2024. doi:10.1016/j.ajhg.2024.01.006