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Publications

Inhibition of the proline metabolism rate-limiting enzyme P5CS allows proliferation of glutamine-restricted cancer cells.

Linder SJ, Bernasocchi T, Martinez-Pastor B, et al. Inhibition of the proline metabolism rate-limiting enzyme P5CS allows proliferation of glutamine-restricted cancer cells. Nature metabolism. 2023. doi:10.1038/s42255-023-00919-3

DNA-encoded library-enabled discovery of proximity-inducing small molecules.

Mason JW, Chow YT, Hudson L, et al. DNA-encoded library-enabled discovery of proximity-inducing small molecules. Nature chemical biology. 2023. doi:10.1038/s41589-023-01458-4

Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes.

Zhang F, Jonsson AH, Nathan A, et al. Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes. Nature. 2023;623(7987):616-624. doi:10.1038/s41586-023-06708-y

High-Resolution and Noninvasive Fetal Exome Screening.

Brand H, Whelan CW, Duyzend M, et al. High-Resolution and Noninvasive Fetal Exome Screening. The New England journal of medicine. 2023;389(21):2014-2016. doi:10.1056/NEJMc2216144

Diversity, evolution, and classification of the RNA-guided nucleases TnpB and Cas12.

Altae-Tran H, Shmakov SA, Makarova KS, et al. Diversity, evolution, and classification of the RNA-guided nucleases TnpB and Cas12. Proceedings of the National Academy of Sciences of the United States of America. 2023;120(48):e2308224120. doi:10.1073/pnas.2308224120

Discovery of antibiotics that selectively kill metabolically dormant bacteria.

Zheng EJ, Valeri JA, Andrews IW, et al. Discovery of antibiotics that selectively kill metabolically dormant bacteria. Cell chemical biology. 2023. doi:10.1016/j.chembiol.2023.10.026

Spatial host-microbiome sequencing reveals niches in the mouse gut.

Lötstedt B, Stražar M, Xavier R, Regev A, Vickovic S. Spatial host-microbiome sequencing reveals niches in the mouse gut. Nature biotechnology. 2023. doi:10.1038/s41587-023-01988-1

Genetic retargeting of E3 ligases to enhance CAR T cell therapy.

Lane IC, Kembuan G, Carreiro J, et al. Genetic retargeting of E3 ligases to enhance CAR T cell therapy. Cell chemical biology. 2023. doi:10.1016/j.chembiol.2023.10.024

CHARR efficiently estimates contamination from DNA sequencing data.

Lu W, Gauthier LD, Poterba T, et al. CHARR efficiently estimates contamination from DNA sequencing data. American journal of human genetics. 2023;110(12):2068-2076. doi:10.1016/j.ajhg.2023.10.011

X-CHIME enables combinatorial, inducible, lineage-specific and sequential knockout of genes in the immune system.

LaFleur MW, Lemmen AM, Streeter ISL, et al. X-CHIME enables combinatorial, inducible, lineage-specific and sequential knockout of genes in the immune system. Nature immunology. 2023. doi:10.1038/s41590-023-01689-6