Publications

Engineered bacterial lipoate protein ligase A (lplA) restores lipoylation in cell models of lipoylation deficiency.

Bick NR, Dreishpoon MB, Perry A, et al. Engineered bacterial lipoate protein ligase A (lplA) restores lipoylation in cell models of lipoylation deficiency. The Journal of biological chemistry. 2024;300(12):107995. doi:10.1016/j.jbc.2024.107995

Loss of function reduces the risk for age-related macular degeneration.

Reeve MP, Loomis S, Nissilä E, et al. Loss of function reduces the risk for age-related macular degeneration. medRxiv : the preprint server for health sciences. 2024. doi:10.1101/2024.11.11.24317117

Analysis of 1386 epileptogenic brain lesions reveals association with DYRK1A and EGFR.

Boßelmann CM, Leu C, Brünger T, et al. Analysis of 1386 epileptogenic brain lesions reveals association with DYRK1A and EGFR. Nature communications. 2024;15(1):10429. doi:10.1038/s41467-024-54911-w

Paired analysis of host and pathogen genomes identifies determinants of human tuberculosis.

Luo Y, Huang CC, Howard NC, et al. Paired analysis of host and pathogen genomes identifies determinants of human tuberculosis. Nature communications. 2024;15(1):10393. doi:10.1038/s41467-024-54741-w

Social and genetic diversity in first farmers of central Europe.

Gelabert P, Bickle P, Hofmann D, et al. Social and genetic diversity in first farmers of central Europe. Nature human behaviour. 2024. doi:10.1038/s41562-024-02034-z

Suppression of Huntington's Disease Somatic Instability by Transcriptional Repression and Direct CAG Repeat Binding.

Mathews EW, Coffey SR, Gärtner A, et al. Suppression of Huntington’s Disease Somatic Instability by Transcriptional Repression and Direct CAG Repeat Binding. bioRxiv : the preprint server for biology. 2024. doi:10.1101/2024.11.04.619693

Human cartilage model of the precocious osteoarthritis-inducing p.Arg719Cys reveals pathology-driving matrix defects and a failure of the ER proteostasis network to recognize the defective procollagen-II.

Yammine KM, Abularach SM, Xiong M, et al. Human cartilage model of the precocious osteoarthritis-inducing p.Arg719Cys reveals pathology-driving matrix defects and a failure of the ER proteostasis network to recognize the defective procollagen-II. bioRxiv : the preprint server for biology. 2024. doi:10.1101/2024.11.07.622468

Synovial tissue myeloid dendritic cell subsets exhibit distinct tissue-niche localization and function in health and rheumatoid arthritis.

MacDonald L, Elmesmari A, Somma D, et al. Synovial tissue myeloid dendritic cell subsets exhibit distinct tissue-niche localization and function in health and rheumatoid arthritis. Immunity. 2024. doi:10.1016/j.immuni.2024.11.004

Safer and efficient base editing and prime editing via ribonucleoproteins delivered through optimized lipid-nanoparticle formulations.

Hołubowicz R, Du SW, Felgner J, et al. Safer and efficient base editing and prime editing via ribonucleoproteins delivered through optimized lipid-nanoparticle formulations. Nature biomedical engineering. 2024. doi:10.1038/s41551-024-01296-2

Circulating tumor-reactive KIRCD8 T cells suppress anti-tumor immunity in patients with melanoma.

Lu BY, Lucca LE, Lewis W, et al. Circulating tumor-reactive KIRCD8 T cells suppress anti-tumor immunity in patients with melanoma. Nature immunology. 2024. doi:10.1038/s41590-024-02023-4