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Publications

Improving Polygenic Risk Scores for Coronary Artery Disease: What Helps and by How Much?

Ajufo EC, Aragam KG. Improving Polygenic Risk Scores for Coronary Artery Disease: What Helps and by How Much? JACC. Basic to translational science. 2023;8(12):1500-1502. doi:10.1016/j.jacbts.2023.10.005

Antigen presentation deficiency, mesenchymal differentiation, and resistance to immunotherapy in the murine syngeneic CT2A tumor model.

Iorgulescu B, Ruthen N, Ahn R, et al. Antigen presentation deficiency, mesenchymal differentiation, and resistance to immunotherapy in the murine syngeneic CT2A tumor model. Frontiers in immunology. 2023;14:1297932. doi:10.3389/fimmu.2023.1297932

Genotype imputation accuracy and the quality metrics of the minor ancestry in multi-ancestry reference panels.

Shi M, Tanikawa C, Munter HM, et al. Genotype imputation accuracy and the quality metrics of the minor ancestry in multi-ancestry reference panels. Briefings in bioinformatics. 2023;25(1). doi:10.1093/bib/bbad509

Unsupervised and supervised AI on molecular dynamics simulations reveals complex characteristics of HLA-A2-peptide immunogenicity.

Weber JK, Morrone JA, Kang SG, et al. Unsupervised and supervised AI on molecular dynamics simulations reveals complex characteristics of HLA-A2-peptide immunogenicity. Briefings in bioinformatics. 2023;25(1). doi:10.1093/bib/bbad504

GDF11 and aging biology - controversies resolved and pending.

Ben Driss L, Lian J, Walker RG, et al. GDF11 and aging biology - controversies resolved and pending. The journal of cardiovascular aging. 2023;3(4). doi:10.20517/jca.2023.23

MAESTRO-Pool Enables Highly Parallel and Specific Mutation-Enrichment Sequencing for Minimal Residual Disease Detection in Cohort Studies.

Blewett T, Rhoades J, Liu R, et al. MAESTRO-Pool Enables Highly Parallel and Specific Mutation-Enrichment Sequencing for Minimal Residual Disease Detection in Cohort Studies. Clinical chemistry. 2023. doi:10.1093/clinchem/hvad203

Single-cell functional genomics reveals determinants of sensitivity and resistance to natural killer cells in blood cancers.

Dufva O, Gandolfi S, Huuhtanen J, et al. Single-cell functional genomics reveals determinants of sensitivity and resistance to natural killer cells in blood cancers. Immunity. 2023;56(12):2816-2835.e13. doi:10.1016/j.immuni.2023.11.008

Natural history of Ebola virus disease in rhesus monkeys shows viral variant emergence dynamics and tissue-specific host responses.

Normandin E, Triana S, Raju SS, et al. Natural history of Ebola virus disease in rhesus monkeys shows viral variant emergence dynamics and tissue-specific host responses. Cell genomics. 2023;3(12):100440. doi:10.1016/j.xgen.2023.100440

Discovery of a structural class of antibiotics with explainable deep learning.

Wong F, Zheng EJ, Valeri JA, et al. Discovery of a structural class of antibiotics with explainable deep learning. Nature. 2023. doi:10.1038/s41586-023-06887-8

Proteolysis-targeting chimeras with reduced off-targets.

Nguyen TM, Sreekanth V, Deb A, et al. Proteolysis-targeting chimeras with reduced off-targets. Nature chemistry. 2023. doi:10.1038/s41557-023-01379-8