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Publications

Parallelized engineering of mutational models using piggyBac transposon delivery of CRISPR libraries.

Nuttle X, Burt ND, Currall B, et al. Parallelized engineering of mutational models using piggyBac transposon delivery of CRISPR libraries. Cell reports methods. 2023:100672. doi:10.1016/j.crmeth.2023.100672

Will variants of uncertain significance still exist in 2030?

Fowler DM, Rehm HL. Will variants of uncertain significance still exist in 2030?. American journal of human genetics. 2023. doi:10.1016/j.ajhg.2023.11.005

Improving fine-mapping by modeling infinitesimal effects.

Cui R, Elzur RA, Kanai M, et al. Improving fine-mapping by modeling infinitesimal effects. Nature genetics. 2023. doi:10.1038/s41588-023-01597-3

A genetic history of the Balkans from Roman frontier to Slavic migrations.

Olalde I, Carrión P, Mikić I, et al. A genetic history of the Balkans from Roman frontier to Slavic migrations. Cell. 2023;186(25):5472-5485.e9. doi:10.1016/j.cell.2023.10.018

Tobacco smoke exposure recruits inflammatory airspace monocytes that establish permissive lung niches for .

Corleis B, Tzouanas CN, Wadsworth MH, et al. Tobacco smoke exposure recruits inflammatory airspace monocytes that establish permissive lung niches for . Science translational medicine. 2023;15(725):eadg3451. doi:10.1126/scitranslmed.adg3451

Dynamic regulatory elements in single-cell multimodal data implicate key immune cell states enriched for autoimmune disease heritability.

Gupta A, Weinand K, Nathan A, et al. Dynamic regulatory elements in single-cell multimodal data implicate key immune cell states enriched for autoimmune disease heritability. Nature genetics. 2023;55(12):2200-2210. doi:10.1038/s41588-023-01577-7

Inferring compound heterozygosity from large-scale exome sequencing data.

Guo MH, Francioli LC, Stenton SL, et al. Inferring compound heterozygosity from large-scale exome sequencing data. Nature genetics. 2023. doi:10.1038/s41588-023-01608-3

A genomic mutational constraint map using variation in 76,156 human genomes.

Chen S, Francioli LC, Goodrich JK, et al. A genomic mutational constraint map using variation in 76,156 human genomes. Nature. 2023. doi:10.1038/s41586-023-06045-0

Dictionary of immune responses to cytokines at single-cell resolution.

Cui A, Huang T, Li S, et al. Dictionary of immune responses to cytokines at single-cell resolution. Nature. 2023. doi:10.1038/s41586-023-06816-9

Slide-tags enables single-nucleus barcoding for multimodal spatial genomics.

Russell AJC, Weir JA, Nadaf NM, et al. Slide-tags enables single-nucleus barcoding for multimodal spatial genomics. Nature. 2023. doi:10.1038/s41586-023-06837-4